phenylacetic acid

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phenylacetic acid

[¦fen·əl·ə′sēd·ik ′as·əd]

(organic chemistry)

C₈H₈O₂ White crystals with a boiling point of 262°C; soluble in alcohol and ether; used in perfumes, medicine, and flavoring and in the manufacture of penicillin. Also known as α-toluic acid.

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Release date- 12082019 - Mallinckrodt plc (NYSE: MNK), a global biopharmaceutical company, today confirmed enrollment of the first patient in the company's Phase 2a study assessing the pharmacokinetics, pharmacodynamics and safety of the oral investigational drug MNK-6106 (L-ornithine phenylacetate) versus rifaximin in patients with hepatic (liver) cirrhosis and hepatic encephalopathy (HE).

First Patient Enrolled in Mallinckrodt's Phase 2a Study of Investigational Drug MNK-6106 in Hepatic Cirrhosis and Chronic Hepatic Encephalopathy

Mallinckrodt plc a global biopharmaceutical company, today confirmed enrollment of the first patient in the company's Phase 2a study assessing the pharmacokinetics, pharmacodynamics and safety of the oral investigational drug MNK-6106 (L-ornithine phenylacetate) versus rifaximin in patients with hepatic (liver) cirrhosis and hepatic encephalopathy (HE).

United Kingdom : First Patient Enrolled in Mallinckrodt's Phase 2a Study of Investigational Drug MNK-6106 in Hepatic Cirrhosis and Chronic Hepatic Encephalopathy (HE)

The arylesterase and paraoxonase activities of PON1 were measured spectrophotometrically using the substrates phenylacetate and paraoxon (O, O-diethyl O-(4-nitrophenyl) phosphate), respectively [23].

Gender-dependent difference in serum paraoxonase 1 levels of Hanwoo, Korean native cattle, and a positive association with meat quality

Arylesterase activity of paraoxonase 1 (POX-1) was measured spectrophotometrically using phenylacetate as a substrate (28-29).

Phytoconstituents and Hepatoprotective Effect of Suaeda monoica Forssk and Suaeda pruinosa Lange

In the study, 10 patients transitioned to Raviciti from sodium phenylbutyrate, three transitioned from intravenous sodium benzoate and sodium phenylacetate, and three were treatment naive.

Horizon Pharma Receives FDA Nod to Expand the Age Range for Raviciti (glycerol phenylbutyrate) Oral Liquid to Include Newborns

The phenylacetate technique (SigmaAldrich) was used to measure the activity ofthis enzyme.

Aqueous wheat extract (Triticuma estivum) prevents carboplatin-induced myelosuppression and oxidative stress in Wistar rats/Extrato aquoso de trigo (Triticum aestivum) na prevencao da mielossupressao e estresse oxidativo induzidos pela carboplatina em ratos Wistar

Also, although the two enzymes have different natural substrates, the PON has the ability to hydrolyse phenylacetate, the natural substrate of ARE.

Serum Antioxidative Enzymes Levels and Oxidative Stress Products in Children and Adolescents with Type I Diabetes Mellitus

Dual investigation of lanthanide complexes with cinnamate and phenylacetate ligands: Study of the cytotoxic properties and the catalytic oxidation of styrene, Polyhedron, 80: 117-128, 2014.

Synthesis, antibacterial activity and DNA interactions of lanthanide(III) complexes of N(4)-substituted thiosemicarbazones/Sintesis, actividad antibacterial e interacciones con DNA de complejos lantanidos (III) de Tiosemicarbazonas N(4)-sustituidas/Sintese, atividade antibacteriana e interacoes com DNA de complexos lantanideos (III) de tiosemicarbazonas N(4)-substituidas

Treatment with sodium benzoate and sodium phenylacetate, used in urea cycle disorders, is recommended if the ammonium levels are greater than 100 uM [27].

Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy

Moreover, phenylacetylglutamine is a product that is formed by the conjugation of phenylacetate and glutamine.

Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications

In detail, sweetness, umami, richness, and acceptance, marked with small circles, were closely located with ethyl phenylacetate, 5-methyl furfural, amyl cinnamal, ethyl myristate, decyl aldehyde, 1-phenylethyl acetate, 1-octen-3-ol, 3-buten-2-ol, butanoic acid, and caproaldehyde on the right side along the X-matrix.

Correlation of Volatile Compounds and Sensory Attributes of Chinese Traditional Sweet Fermented Flour Pastes Using Hierarchical Cluster Analysis and Partial Least Squares-Discriminant Analysis

(vi) Arylesterase enzymatic activity of paraoxonase-1 (PON-1) was assayed by measuring initial hydrolysis rates of phenylacetate as described in detail in previous reports [14,16,22].

Testing a Combination of Markers of Systemic Redox Status as a Possible Tool for the Diagnosis of Late Onset Alzheimer's Disease