We purchased human HepG2 (hepatocellular carcinoma) cells from the American Type Culture Collection (ATCC, Manassas, VA); Mitochondrial Membrane Potential Indicator (m-MPI) from Codex Biosolutions (Montgomery Village, MD); and carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone
(FCCP) from Sigma-Aldrich (St.
Preparation of the Phenylhydrazone
Derivatives of VBOPE (Hydrazone Monomer)
in which phenylhydrazone
with a substituent side and a vacant one in the two ortho-positions was cyclized on the substituent site.
Isomeric 3-substituted 1,2-benzisothiazole1,1-dioxides, [BIDs], with a phenylhydrazone
in the 3-position were ruled out as possible products.
Summary Three benzaldehyde phenylhydrazone
derivatives and three benzophenone-amine derivatives were synthesized and evaluated as vulcanizing accelerators in NR mixes.
The 1,4-dianions of hydrazones, such as 4'-mehoxyacetophenone phenylhydrazone
or 4'-bromoacetophenonre carbomethoxyhydrazone, were prepared in excess lithium diisopropylamide and condensed with phthalic or 1,2-cyclohexanedicarboxylic anhydride, to give C-acylated intermediate that could be isolated or cyclized to the expected pyrazole-carboxylic acid.
Karczmarzyk, A new synthesis of pyrazolo[4,3-e][l,2,4]- triazines via acid promoted ring closure of the phenylhydrazones
Peculiarity of methoxy group- substituted phenylhydrazones
in Fischer indole synthesis Yasuoki MURAKAMI Communicated by Takao SEKIYA, M.
Dilithiated oximes, phenylhydrazones
or carboalkoxyhydrazones were prepared in excess lithium diisopropylamide [LDA] and condensed with polylithiated methyl (2-amino-sulfonyl)benzoate to give C-acylated intermediates that can be isolated or cyclized to the 5-(2-amino-sulfonyl)phenyl-3-aryl-1H-pyrazoles and 5-(2-aminosulfonyl)pheny 1-3-arylisoxazoles.
The extension of the condensation-cyclization of acetophenones with other 1,4-dianion-type systems, such as dilihiated acetophenone phenylhydrazones
or carboalkoxyhydrazones, will also be presented.
The oximes, phenylhydrazones
, or other hydrazones of C([alpha])-ketones, such as 2-aceto-naphthone and 4-chloroacetophenone, were dilithiated with lithium diisopropylamide.
Cyclization of Dilithiated Oximes, Phenylhydrazones