Phlorizin


Also found in: Dictionary, Medical, Wikipedia.

Phlorizin

 

(also phlorhizin, phloridzin, phlorrhizin), an organic compound belonging to the glycoside group; the O-glyco-side of phloroglucinol (1,3,5-trihydroxy-benzene) combined with a residue of phloretinic (β-parahydroxy-phenylpropionic) acid. Phlorizin is found in the roots, stems, and baric of plum, cherry, pear, and apple trees. It is used in biochemical and physiological research.

When injected into animals, phlorizin blocks the reverse absorption (reabsorption) of glucose into the blood from the renal tubules. As a result, glucose is discharged with urine (glycosuria) even though its level in the blood is not abnormally high. Experiments with phlorizin have made it possible to establish that an unvarying level of glucose in the blood is maintained initially by the breakdown of glycogen; subsequently, gluconeogenesis occurs, that is, the formation of glucose from noncarbohydrate precursors—intermediates of the tricarboxylic acid cycle. Phlorizin also inhibits photophosphorylation in chloroplasts and phosphorylation in mitochondria.

Mentioned in ?
References in periodicals archive ?
investigation of the protective effects of phlorizin on diabetic cardiomyopathy in db/db mice by quantitative proteomics.
Antioxidant Products: AppleZin apple polyphenols (80%) with phlorizin (5%); BerryVin high ORAC berry powder; BioVin full spectrum grape extract; black currant extract (30% anthocyanins); BroccoPhane broccoli sprout extract (sulforaphane); BroccoPlus sulforaphane and 6% glucosinolates; BroccoSinolate broccoli powder standardized (4% glucosinolates); CranVida cranberry extract; PomActiv pomegranate extract (70% ellagic acid); Q-Vida quebracho extract
Effects of hyperglycemia on glucose transporters of the muscle: use of the renal glucose reabsorption inhibitor phlorizin to control glycemia.
French researchers found they contain a flavonoid called phlorizin, which can increase the density of your bones and may help to protect post-menopausal women from the brittle bone disease osteoporosis.
French scientists have discovered that apples contain flavonoids called phlorizin that protect bones from the brittle bone disease osteoporosis.