Phlorizin


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Phlorizin

 

(also phlorhizin, phloridzin, phlorrhizin), an organic compound belonging to the glycoside group; the O-glyco-side of phloroglucinol (1,3,5-trihydroxy-benzene) combined with a residue of phloretinic (β-parahydroxy-phenylpropionic) acid. Phlorizin is found in the roots, stems, and baric of plum, cherry, pear, and apple trees. It is used in biochemical and physiological research.

When injected into animals, phlorizin blocks the reverse absorption (reabsorption) of glucose into the blood from the renal tubules. As a result, glucose is discharged with urine (glycosuria) even though its level in the blood is not abnormally high. Experiments with phlorizin have made it possible to establish that an unvarying level of glucose in the blood is maintained initially by the breakdown of glycogen; subsequently, gluconeogenesis occurs, that is, the formation of glucose from noncarbohydrate precursors—intermediates of the tricarboxylic acid cycle. Phlorizin also inhibits photophosphorylation in chloroplasts and phosphorylation in mitochondria.

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Keywords: Sweet active components; Lithocarpus polystachyus Rehd.; Phlorizin; Trilobatin; NMR; Artificial cultivation.
Wang et al., "Insulin sensitivity-enhancing activity of phlorizin is associated with lipopolysaccharide decrease and gut microbiota changes in obese and type 2 diabetes (db/db) mice," Journal of Agricultural and Food Chemistry, vol.
Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: The role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter.
Baratti, "Phlorizin, a competitive inhibitor of glucose transport, facilitates memory storage in mice," Neurobiology of Learning and Memory, vol.
Effect of phlorizin on SGLT2 expression in the kidney of diabetic rats.
Treatment off streptozotocin induced diabetic rats with Vanadate and Phlorizin prevents the over expression of liver insulin receptor gene.
INTRODUCTION: Adult type hypolactasia develops due to decreased activity of the enzyme lactase phlorizin hydrolase and stops its synthesis in mammals after the weaning period.
Part two covers structure-activity details of some particular drug successes, including epothilones, taxol, camptothecin, morphine, lincosamide, platensimycin, phlorizin, aeruginosins, and their analogs.
Liou, "Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages," Food Chemistry, vol.
Phlorizin [16], 3-(benzo[b]furan5-yl) -2,,6,-dihydroxy-4,-methylpropiophenone-2,-O-[beta]-D-glucopyranoside [17], sergliflozin [18], and remogliflozin [19] are O-glycosides and show strong inhibition of SGLT2.
French scientists have discovered apples strengthen bones through a flavonoid called phlorizin that protects from osteoporosis.
Abnormal B-cell function in rats with non-insulin-dependent diabetes induced by neonatal streptozotocin: effect of in vivo insulin, phlorizin, or vanadate treatments.