Phosphocreatine


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Related to Phosphocreatine: creatine kinase

phosphocreatine

[¦fäs·fō′krē·ə‚tēn]
(biochemistry)
C4H10N3O5P Creatine phosphate, a phosphoric acid derivative of creatine which contains an energy-rich phosphate bond; it is present in muscle and other tissues, and during the anaerobic phase of muscular contraction it hydrolyzes to creatine and phosphate and makes energy available. Abbreviated PC.

Phosphocreatine

 

(creatine phosphate, creatine phosphoric acid), a product of creatine phosphorylation; an energy-rich compound.

Phosphocreatine was first discovered in 1927 in fresh specimens of muscle tissue. It can be prepared by treating creatine with POCI3 in an alkaline medium. One of the energy sources for muscle contraction is the readily reversible decomposition of phosphocreatine, catalyzed by the enzyme creatinase: phosphocreatine + ADP ⇄ creatine + ATP. A decrease in the ATP content in the tissues leads to the decomposition of phosphocreatine; an increase in ATP content leads to its synthesis. Thus, phosphocreatine forms a reserve of energy-rich phosphate, both the phosphate and stored energy of which can be used in the formation of ATP. In tissues, phosphocreatine undergoes gradual spontaneous decomposition to yield inorganic phosphate and creatinine, which is eliminated with the urine. Arginine phosphate replaces phosphocreatine in many invertebrates (for example, insects).

N. P. MESHKOVA

References in periodicals archive ?
CK has the main function in energy metabolism, where it works like a buffer system of levels of cellular ATP; it catalyzes the reversible transfer of the phosphoryl group of phosphocreatine to ADP, regenerating ATP (Warchala et al.
The mitochondria also replenish this phosphocreatine store after muscle contraction.
To conclude, the primary energy source for short indoor track events--sprinting distances up to 400 meters--is phosphocreatine.
174) Because of the absence of the phosphocreatine shuttle in mammalian sperm, it is postulated that glycolytic machinery would provide ATP throughout the flagellum.
Izquierdo M et al showed that fatigue in short duration sports is mainly due to low concentration of phosphocreatine rather than accumulation of acid lactic.
Inside the body creatine is converted into phosphocreatine and stored in muscle.
In addition, given the highly anaerobic nature of the fatigue bout used in the present study, improved energy production could only come from enhancing the performance of the phosphocreatine system and/or anaerobic glycolysis.
This study, combined with other work recently published by the Wray lab on the phosphocreatine cycle (Pfefferle et al.
One-third of creatine in the skeletal muscle is free creatine and the other two-thirds is phosphocreatine.
Single proton MRS (1H-MRS) enables measurement of glutamate (Glu), glutamine (Gln), N-acetyl-L-aspartate (NAA), choline compounds (Cho), creatine and phosphocreatine (Cre), myoinositol (mI) and lactate.
The energy in your body is stored in molecules called ATP (adenosine triphosphate) as well as phosphocreatine.