phthalazine


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phthalazine

[′thal·ə‚zēn]
(organic chemistry)
C6H4CHN2CH Colorless crystals, melting at 91°C; soluble in alcohol.
References in periodicals archive ?
As a continuation of our interest in the reactions between methionine- and histidine-containing peptides and dinuclear Pt(II) complexes with six-membered aromatic diazines as bridging ligands, in the present study, we describe synthesis and characterization of three new dinuclear platinum(II) complexes, [[{Pt(en)Cl}.sub.2]([mu]-qx)][Cl.sub.2] x 2[H.sub.2]O (1), [[{Pt(en)Cl}.sub.2]([mu]-qz)][(Cl[O.sub.4]).sub.2] (2), and [[{Pt(en)Cl}.sub.2]([mu]-phtz)] [Cl.sub.2] x 4[H.sub.2]O (3) (qx = quinoxaline, qz = quinazoline, phtz = phthalazine, and en = ethylenediamine).
The compounds [D.sub.2]O, DN[O.sub.3], NaOD, ethylenediamine (en), quinoxaline (1,4-benzodiazine, qx), quinazoline (1,3-benzodiazine, qz), phthalazine (2,3-benzodiazine, phtz), and [K.sub.2][Pt[Cl.sub.4]] were obtained from Sigma-Aldrich Chemical Co.
The dmf solution of the ligand L (0.0297 g; 0.228 mmol) (L is quinoxaline, qx; quinazoline, qz; and phthalazine, phtz) was added dropwise to the solution of [Pt(en)(dmf)Cl]N[O.sub.3] complex.
Three aromatic N-heterocycles, quinoxaline (qx), quinazoline (qz), and phthalazine (phtz) (Figure 1(a)), were used as the bridging ligands between two {Pt(en)Cl} units.
Mohamad, "Molecular dynamic and quantum chemical calculations for phthalazine derivatives as corrosion inhibitors of mild steel in 1M HCl," Corrosion Science, vol.
Heterocyclic compounds containing phthalazine moiety have attracted considerable attention in recent years owing to their pharmacological and biological activities [14] such as anticonvulsant [15], cardiotonic [16] and vasorelaxant activities [17].
Timbrell, Determination of Hydralazine Metabolites: 4-hydrazino-phthalazin-1-one and N-acetylhydrazinophthalazin-1-one by Gas Chromatography and S-Triazolo[3,4-alpha] phthalazine and phthalazinone by High-Performance Liquid Chromatography.
Caption: Figure 16: Phthalazine, quinazoline, and quinoxaline analogues of thiazolidinedione.
Gouda, "Synthesis and antibacterial activity of some new heterocycles incorporating phthalazine," European Journal of Medicinal Chemistry, vol.
Varma, "Aqueous N-heterocyclization of primary amines and hydrazines with dihalides: microwave-assisted syntheses of N-azacycloalkanes, isoindole, pyrazole, pyrazolidine, and phthalazine derivatives," Journal of Organic Chemistry, vol.
These alkaloids include quinazoline, quinaxaline, cinnoline, phthalazine and other three or four membered ring azaheterocycles such as, pteridine, alloxazine, isoalloxazine [1].
The search for multicomponent reaction has paved a considerable attention for the use of phthalazine derivatives which has gained importance during recent year, which may be attributed to their wide range of pharmacological and biological activities [2].