Also found in: Dictionary, Wikipedia.


(organic chemistry)
C8H5NO2 The product made by heating phthalic anhydride with ammonia; used in Gabriel's synthesis of primary amines, amino acids, and anthranilic acid (o-aminobenzoic acid).
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a colorless crystalline substance, with limited solubility in water and alcohol and a boiling point of 238°C. Exhibiting the properties of a weak acid, phthalimide interacts with alkaline solutions, for example, to form metallic derivatives, such as C8H4O2NK, which are used for the synthesis of primary amines

and α-amino acids (Gabriel’s reaction) in the production of anthranilic acid. N-halogen-substituted phthalimides, obtained by the interaction of phthalimide with chlorine and bromine, for example, C8H4O2NBr, are used in laboratory practice for the halogenation of organic compounds. Phthalimide is prepared from phthalic anhydride and the carbonate of ammonium or ammonia.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
In this study, the protein denaturation bioassay was performed for in vitro assessment of anti-inflammatory activity of phthalimide derivatives.
Ismail, "Effects of non-ionic and mixed cationic--non-ionic micelles on the rate of alkaline hydrolysis of phthalimide," Journal of Physical Organic Chemistry, vol.
The LOI values of the epoxy resins increase linearly with increasing the phthalimide groups and phosphorous contents (Figure 8).
For all statistically significant associations, the number of positive t(14;18) cases exceeded the number of negative t(14;18) cases (e.g., lindane, cyclodienes as a class, dieldrin, toxaphene, atrazine, phthalimide, and a fumigant).
Trichloromethyl phythalimido disulfide was prepared by the reaction of potassium phthalimide with trichloromethane thiosulfenyl chloride as shown in Scheme 3.
(1.) Cavitt, TB, Nguyen, CK, Hoyle, CE, Phillips, B, Daniels, C, Kalyanaraman, V, Jonsson, S, "Mechanisitic Elucidation of Both Maleic Anhydride and Phthalimide Photoinitiating Systems." In: RadTech 2002 Proceedings, p.
Comparative investigation on the mutagenicities of organophosphate, phthalimide, pyrethroid and carbamate insecticides by the Ames and Iactam tests.
The protection and deprotection of potassium phthalimide significantly reduce the atom economy, yield, and increase the impurities as well as number of steps [20, 21].
There were synthesized copolymers of N-isopropylacrylamide, N-acryloyl phthalimide and polyacrylamide studied in the process of immobilizing them trypsin [6-8].
Significant research findings show that these N-arylphthalamic acids induce hyperlipidemia in Swiss white mice and also an increase in body weight of the animals, in contrast with the hypolipidemic activity showed by their phthalimide analogues [6].