Picolines


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Picolines

 

(or methylpyridines), homologues of pyridine. All three isomers (α-, β-, and γ-picolines) are known; they are colorless liquids with a pyridine odor. Melting points, –66.6°, –17.7°, and –4.3°C; boiling points, 129.4°, 144.0°, and 145.3° C; densities at 20°C, 0.9940, 0.9572, and 0.9551 g/cm3, respectively. Picolines are stronger bases than pyridine. They are readily soluble in water and organic solvents.

Oxidation of β-picoline yields nicotinic acid (antipellagra vitamin PP, or niacin), the diethylamide of which is cordiamin; oxidation of γ -picoline yields isonicotinic acid, which is the basis of tuberculostatic preparations, such as phthivazid and isoniazid. Pyridoxine (vitamin B6), a derivative of α-picoline, takes part in many important metabolic reactions in its coenzyme form (pyridoxal 5-phosphate).

References in periodicals archive ?
Vertellus will market pyridine and picolines, specialty pyridine derivatives, castor oil derivatives, polymer additives and systems, DEET, citrate polymer additives and systems and sulfone monomers and is also a global producer of Vitamin B-3.
The company is the leading global producer of pyridine and picolines, specialty pyridine derivatives, DEET, castor oil derivatives and systems, and citrate polymer additives and systems, and is the world's second largest producer of vitamin B-3 for both animal feed and human consumption.
Together, these projects provided a 35% increase in capacity for beta picoline, a key raw material input used to produce 3-cyanopyridine and vitamin B3.