Picolines


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Picolines

 

(or methylpyridines), homologues of pyridine. All three isomers (α-, β-, and γ-picolines) are known; they are colorless liquids with a pyridine odor. Melting points, –66.6°, –17.7°, and –4.3°C; boiling points, 129.4°, 144.0°, and 145.3° C; densities at 20°C, 0.9940, 0.9572, and 0.9551 g/cm3, respectively. Picolines are stronger bases than pyridine. They are readily soluble in water and organic solvents.

Oxidation of β-picoline yields nicotinic acid (antipellagra vitamin PP, or niacin), the diethylamide of which is cordiamin; oxidation of γ -picoline yields isonicotinic acid, which is the basis of tuberculostatic preparations, such as phthivazid and isoniazid. Pyridoxine (vitamin B6), a derivative of α-picoline, takes part in many important metabolic reactions in its coenzyme form (pyridoxal 5-phosphate).

References in periodicals archive ?
Vertellus is the world's largest producer of pyridine and picolines, specialty pyridine derivatives, DEET, castor oil derivatives and systems, and citrate polymer additives and systems, and the world's second largest producer of Vitamin B3.
Vertellus is the leading global producer of pyridine and picolines, specialty pyridine derivatives, DEET, castor oil derivatives and systems, and citrate polymer additives and systems, and is the world's second largest producer of vitamin B3.
the world's largest producer of pyridine, picolines and pyridine derivatives, has made major recent investments to serve the needs of the global life science markets.
Owning the majority of the outstanding equity of the joint venture, Vertellus will leverage its industry-leading technology to produce pyridine and picolines at the facility.
the world's largest producer of pyridine, picolines and pyridine derivatives, has entered into a joint venture with Weifang Green Olive Chemical Co.
the world's largest producer of pyridine, picolines and pyridine derivatives, announces the hiring of Mike Turner as Director of the Agriculture Business segment.
Together, these projects provided a 35% increase in capacity for beta picoline, a key raw material input used to produce 3-cyanopyridine and vitamin B3.