Pin1 regulates the timing of mammalian primordial germ cell proliferation.
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.
As people get older and older, Pin1 levels drop, drop, drop," Lu says.
Boosting Pin1 levels may help untangle tau in people at risk of Alzheimer's disease, slowing the disease's progression or preventing it altogether.
In the July 31 Nature, Lu, Hunter, and their colleagues report that mice with an inactive Pin1
gene suffer nerve cell loss in the spinal cord and brain as the animals age.
According to Pintex, Pin1
deregulation has been found in 38 out of 60 types of human cancer.
enzyme, which has been linked to numerous human cancers, including prostate and breast cancer, may be one of the most prevalent tumor markers found to date.
It also means that the amount of Pin1
present in pre-therapy biopsies may allow doctors to counsel patients diagnosed with potential prostate cancer to wait and see, thereby avoiding or at least delaying surgery or radiation therapy.
It includes polyclonal and monoclonal antibodies, as well as methods for making antibodies to the Pin1
patent application complements our existing comprehensive intellectual property assets, which form the basis for a potentially wide array of new cancer therapies and diagnostics," said Pintex CEO George C.
Hillman said, "The discovery of the role of the Pin1
enzyme in human cancer creates a novel target with significant potential for creating new cancer therapeutics and reducing human suffering.
These funds will be used to continue preclinical development of Pin1
inhibitors and will move the company towards partnerships with pharmaceutical companies focused on oncology.