Piperazine


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piperazine

[pī′par·ə‚zēn]
(organic chemistry)
C4H10N2 A cyclic compound; colorless, deliquescent crystals, melting at 104-107°C; soluble in water, alcohol, glycerol, and glycols; absorbs carbon dioxide from air; used in medicine.

Piperazine

 

(or diethylenediimine), a heterocyclic compound; colorless crystals. Melting point, 104°C; boiling point, 145°-146°C. Poorly soluble in water and ether; readily soluble in alcohol.

Piperazine is a strong base. It is obtained by hydrogenation of pyrazine or 2,5-piperazinedione or condensation of dibromo-ethane with ammonia. Piperazine and its derivatives are used in analytical chemistry for microcrystalloscopic identification of Mo, V, and W and in medicine (in the form of salts of adipinic, citric, phosphoric, or sulfuric acid) as an anthelmintic in cases of ascariasis and enterobiasis.

References in periodicals archive ?
2010) found that urea derivatives that contain piperazine rings were effective in blocking calcium ion channel activity.
Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl) piperazine (TFMPP).
These substances, which can be mixed together to vary the effects, include mephedrone and MDPV, which are often sold as "bath salts" or "plant food"; and piperazine.
In 2011, the Hong Kong Government added three synthetic substances to the Dangerous Drugs Ordinance and one chemical to the Control of Chemicals Ordinance, namely, derivatives of piperazine (party pills), synthetic cannabinoids (spice), derivatives of cathinone (bath salts), as well as ketamine precursor chemical 1-[(2-Chlorophenyl)-N-(methylimino)methyl]cyclopentanol and its salts.
international control, such as piperazine and cathinone.
Prosecutor Alisha Kaye told Bradford Crown Court yesterday (FRI) that the package was found to contain 37 tablets of Trifluoromethylphenyl Piperazine.
Treatment with piperazine sulfate significantly reduced the number of adult worms in the intestines, greatly decreased eggs per gram of feces, relieved clinical signs in the flock, and returned the flock mortality back to expected levels.
The results showed that BZP itself was toxic to the kidney and its starting material, piperazine hexahydrate, was toxic to the liver.
The efflux pump inhibitors (EPIs) 1-(1-naphthylmethy1) piperazine (NMP) and phenylarginine-beta-naphthylamide (PAbetaN) are found to inhibit V.
He further revealed that commercial and herbal medicine are very effective by using 2 grams betel nut and one caplet of piperazine plus niclosamide in deworming native chicken but using betel nut is more economical.
Some forms of estrone are present in conjugated and esterified estrogen preparations, as well as in combination with piperazine.
At 5% concentration, all the extracts except petroleum ether and ethyl acetate extracts showed greater activity than the standard drug piperazine citrate.