Piperazine

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piperazine

[pī′par·ə‚zēn]
(organic chemistry)
C4H10N2 A cyclic compound; colorless, deliquescent crystals, melting at 104-107°C; soluble in water, alcohol, glycerol, and glycols; absorbs carbon dioxide from air; used in medicine.

Piperazine

 

(or diethylenediimine), a heterocyclic compound; colorless crystals. Melting point, 104°C; boiling point, 145°-146°C. Poorly soluble in water and ether; readily soluble in alcohol.

Piperazine is a strong base. It is obtained by hydrogenation of pyrazine or 2,5-piperazinedione or condensation of dibromo-ethane with ammonia. Piperazine and its derivatives are used in analytical chemistry for microcrystalloscopic identification of Mo, V, and W and in medicine (in the form of salts of adipinic, citric, phosphoric, or sulfuric acid) as an anthelmintic in cases of ascariasis and enterobiasis.

References in periodicals archive ?
Equimolar amounts of 4-(tert- butylbenzyl)sulfanyl-, ethylsulfanyl-, cyclopentylsulfanyl-, 4-chlorophenylsulfanyl-1,1,2,4- tetrachloro-3-nitro-1,3-butadienes 3a-d were stirred with piperazine derivatives (1-(2-furoyl)-, 1- (tetrahydro-2-furoyl)-, 1-(tetrahydro-2-furylmethyl)-1-piperonyl- and bis(4-fluoro-phenyl)methyl- substituted piperazines 4, 6, 8, 10 and 12 in 10 mL dichloromethane for 24 h at room temperature.
The novel N,S-Substituted trichloronitrodienes 5a-d, 7a-c, 9a-c, 11a, and 13b-c were synthesized by the reaction of the S-substituted nitrodienes (3a [4], 3b [5], 3c [6], and 3d [3]) with 2-furoyl-, tetrahydro-2-furoyl-, tetrahydro-2- furylmethyl-, 1-piperonyl- and bis(4-fluoro- phenyl)methyl- substituted piperazines (4, 6, 8, 10 and 12) in dichloromethane at room temperature, respectively in Scheme 3.
Piperazines are a class of compounds that are often sold as legal
cannabinoids, synthetic cathinones, phenethylamines, piperazines,
Classical synthetic routes to the unsymmetrically N,N'-diarylated piperazine moiety 1 encompass the reaction of anilines with bis(2-chloroethyl)amine directly (K.
First 1-(4-methoxyphenyl) piperazine were generated in situ from diethanolamine using one-pot synthesis method.
Cinnarizine is a piperazine that exerts calcium channel blocking effects.
These compounds include methoxetamine (an analog to ketamine), kratom (a compound derived from Mitragyna speciosa) and piperazine (an antihelminthic that has been shown to produce amphetamine-like effects).