Piperidine

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Related to Piperdine: piperidine alkaloids

piperidine

[pī′per·ə‚dēn]
(organic chemistry)
C5H11N A cyclic compound, and strong base; colorless liquid with pepper aroma; boils at 106°C; soluble in water, alcohol, and ether; used as a chemical intermediate and rubber accelerator, and in medicine.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Piperidine

 

(or hexahydropyridine), a heterocyclic compound; a colorless liquid with à strong ammoniacal odor. Melting point, –10.5°C; boiling point, 106.4°C; density, 0.8606 g/cm3 at 20°C. Miscible with water and most organic solvents. It is a strong base.

The piperidine ring is a structural fragment of many alkaloids, such as cocaine, lobeline, coniine, and pelletierine. Piperidine was first obtained from piperine, an alkaloid found in black pepper. It is prepared by reduction of pyridine and is used as a catalyst in condensation reactions. Piperidine derivatives are used as medicinal preparations, especially as local anesthetics and spasmolytics.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The results showed that parent compound 4-(4'-Bromophenyl)-4-hydroxy piperdine exhibited no inhibitory response whereas significant activity was shown by the compounds, 1-(1''-Adamantan acyl)-4- (4'- bromophenyl)-4-hydroxy piperidinium Hydrobromide (I) This kind of exhibition due to the substitution of adamantane group in molecule and adamantine is responsible for causing the modulation of neurotransmitter Furthermore quarternization with piperidine ring made it more suitable for cholinergic activity [18].
These novel compounds having the parent moiety 4-(4'-Bromophenyl)-4-hydroxy piperdine were found to prove strong inhibition towards plasmepsin enzyme with 8-10 IC50 in uM and highly significant analgesic response in albino mice.
Keywords: Malaria, Plasmepsin, Piperdine, Analgesics.
Table-1: Substituents of 4-(4'-Bromophenyl)-4- Hydroxy Piperdine.