Piperidine

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Related to Piperdine: piperidine alkaloids

piperidine

[pī′per·ə‚dēn]
(organic chemistry)
C5H11N A cyclic compound, and strong base; colorless liquid with pepper aroma; boils at 106°C; soluble in water, alcohol, and ether; used as a chemical intermediate and rubber accelerator, and in medicine.

Piperidine

 

(or hexahydropyridine), a heterocyclic compound; a colorless liquid with à strong ammoniacal odor. Melting point, –10.5°C; boiling point, 106.4°C; density, 0.8606 g/cm3 at 20°C. Miscible with water and most organic solvents. It is a strong base.

The piperidine ring is a structural fragment of many alkaloids, such as cocaine, lobeline, coniine, and pelletierine. Piperidine was first obtained from piperine, an alkaloid found in black pepper. It is prepared by reduction of pyridine and is used as a catalyst in condensation reactions. Piperidine derivatives are used as medicinal preparations, especially as local anesthetics and spasmolytics.

References in periodicals archive ?
These novel compounds having the parent moiety 4-(4'-Bromophenyl)-4-hydroxy piperdine were found to prove strong inhibition towards plasmepsin enzyme with 8-10 IC50 in uM and highly significant analgesic response in albino mice.
Keywords: Malaria, Plasmepsin, Piperdine, Analgesics.
Table-1: Substituents of 4-(4'-Bromophenyl)-4- Hydroxy Piperdine.
In present study the synthesized derivatives of compounds 4-(4'-Bromophenyl)-4- hydroxy piperdine were evaluated for antimalarial activity.