Piperidine


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Related to Piperidine: piperidine alkaloids

piperidine

[pī′per·ə‚dēn]
(organic chemistry)
C5H11N A cyclic compound, and strong base; colorless liquid with pepper aroma; boils at 106°C; soluble in water, alcohol, and ether; used as a chemical intermediate and rubber accelerator, and in medicine.

Piperidine

 

(or hexahydropyridine), a heterocyclic compound; a colorless liquid with à strong ammoniacal odor. Melting point, –10.5°C; boiling point, 106.4°C; density, 0.8606 g/cm3 at 20°C. Miscible with water and most organic solvents. It is a strong base.

The piperidine ring is a structural fragment of many alkaloids, such as cocaine, lobeline, coniine, and pelletierine. Piperidine was first obtained from piperine, an alkaloid found in black pepper. It is prepared by reduction of pyridine and is used as a catalyst in condensation reactions. Piperidine derivatives are used as medicinal preparations, especially as local anesthetics and spasmolytics.

References in periodicals archive ?
Among heterocyclic compounds, Piperidine has played significant role in drug discovery process [3].
Zhang et al., "Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter," Journal of Medicinal Chemistry, vol.
michiganensis In vitro and the application of piperidine alkaloids to manage symptom development of bacterial canker on tomato in the greenhouse.
Figure 1 demonstrates the load and displacement curves for the epoxy and particle/epoxy systems with the piperidine curing agent, which shows the same tendency of load-displacement curves for different types of particles.
The Pipe and Kim research groups devised a way to strongly link long polymer chains of a plastic called polyacrylic acid (PAA) with short strands of another called polyacryloyl piperidine (PAP).
The reactive hindered piperidine amine, N,N'-bis(2,2,6,6-tetramethyl-4piperi dinyl)--1,6-hexanediamine (HDM) was kindly supplied by Evonik Tianda Chemical Additive Co.
4-t-butyl cyclohexanone, piperidine, paraformaldehyde, acetic acid, hydroxyl amine hydrochloride, sodium acetate, sodium bisulfite, potassium cyanide, diethyl ether and other chemicals were purchased from Merck chemical Co.
In search of other opioids with good analgesic potency and fewer incidence of side effects mainly respiratory depression, a phenyl piperidine derivative fentanyl and thienyl analogue of fentanyl-Sufentanil and many more were discovered and studied.
Fragmentation of the precursor ion at m/z 306.12 [[M+H].sup.+] showed a loss of 17 Da, forming the production of m/z 288 presumably due to the loss of OH group at piperidine ring.
p-Tolualdehyde, sebacoyl chloride, 1,6-hexanediol, DMAP, triethylamine, DMF, and piperidine (Aldrich) were used as received.
This assignment leans on the earlier studies of amino acids lyophilized and deposited onto the colloidal Au surface [27, 28], BK, and its modified analogs [16-18], piperidine (Pip) [29,30] andthiophene (Thi) [31-33].