Plasma Cell


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plasma cell

[′plaz·mə ‚sel]
(histology)

Plasma Cell

 

a type of cell of the connective and hematopoietic tissues. Plasma cells are formed in vertebrates and man from hematopoietic stem cells of the bone marrow. Their principal function is the production of antibodies. Plasma cells are found in lymphatic and hematopoietic tissues, in serous membranes, and in the connective tissues of the organs of digestion and respiration; they accumulate during immunological reactions, for example, to foreign tissues and infection. They are round and have an eccentric nucleus that contains dense clumps of chromatin. The cytoplasm contains large amounts of ribonucleic acid and therefore stains strongly with basic stains. The only region of a plasma cell that absorbs little stain is near the nucleus, where the Golgi complex and the centrosome are located. The plasma cell also exhibits a well-developed endoplasmic reticulum and an abundance of ribosomes, which are characteristic of cells that actively synthesize and secrete proteins.

N. G. KHRUSHCHOV

References in periodicals archive ?
Histopathology is nonspecific with possible salivary gland hyperplasia, duct ectasia, and dermal inflammatory infiltrate (lymphocytes, plasma cells, histiocytes).
There is no study associating intensity of the symptoms with the count of inflammatory plasma cells in Riedel's thyroiditis, but in the spectrum of IgG4 related diseases Deshpande et al.
In conclusion, this case highlights that while myeloma is usually associated with anemia, the presence of polycythemia does not rule out plasma cell myeloma, whether it be symptomatic or smouldering.
To our knowledge, this is the first study reporting that pDC and its secreted IFN-[alpha] induced by TLR9 activation enhance plasma cell differentiation and further facilitate monocytes/macrophages and T lymphocyte infiltration across endothelial cell monolayer in IgAN.
In bone marrow aspirate, the plasma cell percentage varied from 12% to 90%.
This investigation highlights the difficulty of elucidating whether clusters of plasma cell dyscrasias result from chance or if they have a common occupational or environmental cause.
Of all up to date cases of primary cutaneous plasmacytoma, five have been described in which local triggering stimulus from trauma may have contributed to the development of plasma cell proliferation.
Bone marrow biopsy revealed a normocellular bone marrow with trilineage hematopoiesis with no excess blasts but was significant for infiltrating plasma cells. An immunohistochemical stain for CD138 was performed to better quantify the plasma cells in a tissue context and showed singly dispersed and clustered plasma cells comprising approximately 10% of the marrow cellularity.
(1) Risk Stratification, which includes Staging of MM, Plasma Cell Labeling index (PCLI), Cytogenetics and Gene Expression Profiling (GEP)
reported that noncompliant recipients tend to have greater plasma cell densities among inflammatory cells after allograft rejection compared to compliant recipients, although this difference was not significant (10.25 [+ or -] 8.19% versus 8.52 [+ or -] 4.23%, p = not significant) [12].
* A normocellular microscopical appearance, with no plasma cell dyscrasia, was displayed on the bone marrow aspirate.