Plasma Cell

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Related to Plasma cells: Macrophages, Histiocytes, Memory cells

plasma cell

[′plaz·mə ‚sel]

Plasma Cell


a type of cell of the connective and hematopoietic tissues. Plasma cells are formed in vertebrates and man from hematopoietic stem cells of the bone marrow. Their principal function is the production of antibodies. Plasma cells are found in lymphatic and hematopoietic tissues, in serous membranes, and in the connective tissues of the organs of digestion and respiration; they accumulate during immunological reactions, for example, to foreign tissues and infection. They are round and have an eccentric nucleus that contains dense clumps of chromatin. The cytoplasm contains large amounts of ribonucleic acid and therefore stains strongly with basic stains. The only region of a plasma cell that absorbs little stain is near the nucleus, where the Golgi complex and the centrosome are located. The plasma cell also exhibits a well-developed endoplasmic reticulum and an abundance of ribosomes, which are characteristic of cells that actively synthesize and secrete proteins.


References in periodicals archive ?
This process may slow the over-development of plasma cells in multiple myeloma patients or cause these dangerous cells to die.
This results in expansion of plasma cells which produce excessive amounts of antibodies leading to destruction of one's own healthy tissue.
Nonsecretory myelomas are defined by a clinical and anatomical diagnosis of plasma cell dyscrasia with un detectable monoclonal protein in the serum (1).
4,7) In pseudolymphomatous histology, a lymphoplasmacytic appearance predominates with small lymphocytes (mostly T cells), plasma cells (mostly IgG4), follicle formation, and some eosinophils.
Approximately 50% of patients with the plasma cell variant experience systemic manifestations, including fever, anemia, and hyperglobulinemia.
Hoping to glean insights into the role of ERKs in B cell differentiation into plasma cells, the researchers generated mice deficient in two different ERKs, ERK1 and ERK2, and studied the effect of this deficiency on the fate of B cells.
The plasma cell has been designed to be easy to operate and simple to maintain with the added benefit of being compact - a good solution for a small production facility perhaps.
Using large cohorts of myeloma patients, the researchers have identified a profile of genes that are silenced by epigenetic mechanisms in the malignant plasma cell.
2) Alternate terminology includes pulmonary pseudotumor, plasma cell granuloma, inflammatory myofibroblastic tumor, fibroxanthoma, xantho matous pseudotumor, and plasma cell-histiocytoma complex.
0 g/dL as major criteria for diagnosis of plasma cell myeloma.
The fact that plasma cell endometritis persisted in 40% of these women following antibiotic therapy with no identifiable variables that predicted failure raises questions about the importance of identifying plasma cells in the endometrium," Dr.
Histopathologic findings demonstrated ulcers and dermal granulation tissue with linearly arranged eosinophils, mast cells, neutrophils, and plasma cells between dense, homogeneous collagen bundles (sclerosing dermatitis).

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