Plasmalogen


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plasmalogen

[plaz′mal·ə·jən]
(biochemistry)
Any of a group of glycerol-based phospholipids in which a fatty acid group is replaced by a fatty aldehyde.

Plasmalogen

 

any of a group of naturally occurring lipids belonging to phosphoglycerides, or phosphatides. Plasmalogens were first discovered in 1924 in blood plasma. They are widely distributed in animal tissues, for example, the brain, heart, and skeletal muscles, as well as in plant tissues, for example, algae and the fruits of leguminous plants.

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Phospholipids in ram semen: metabolism of plasmalogen and fatty acids.
Biochemical investigations like RBC plasmalogen levels and phytanic acid levels could not be done because of financial constraints.
2] Rhizomelic chondrodysplasia punctata is a disorder caused by abnormal peroxisomal function which can be mediated both through disorders of biosynthesis, for example, peroxisomal assembly (RDCP1) and by single enzyme defects affecting plasmalogen synthesis (RCDP2, RCDP3).
Peroxisomes are single-membrane-bounded ubiquitous organelles containing a hundred different enzymes that catalyze various metabolic pathways, including O-oxidation of very long-chain fatty acids, the synthesis of ether lipids such as plasmalogens, and bile-acid metabolism (1) (Table 1).
Two methods were developed for the isolation of mammalian somatic cell mutants defective in peroxisome biogenesis: (i) colony autoradiographic screening with a phenotypic marker, dihydroxyacetonephosphate acyltransferase (DHAP-ATase) deficiency; (28),(29) and (ii) the photo-sensitized selection method using 9(1,-pyrene)nonanol (P9OH) and an exposure to long wave-length ultraviolet (UV) light which kills wildtype cells incorporating P9OH as a fatty alcohol into plasmalogens and survive cell mutants deficient in such activity.
The abundance of plasmalogens in molluscs has been previously reported (Joseph 1982, Chapelle 1987, Kraffe et al.
The biological significance of plasmalogens in defense against oxidative damage.
Total fatty acids, plasmalogens, and fatty acid composition of ethanolamine and choline phosphoglycerides.
It mostly exists in the forms of phospholipids phosphatidylcholine (lecithin), lysophosphatidylcholine, choline plasmalogens and sphingomyelin, and is widely distributed in all plant and animal cells (Zeisel, 1990).
In different aquatic ectothermal animals, it has also been reported that plasmalogens increase in response to an elevation of temperature (Yeo et al.
Dimetylacetals (DMA) from PE plasmalogens in the GC analyses were not identified.