Since [alpha]-chloro fatty aldehydes can exclusively be generated by plasmalogen
oxidation, this emphasizes the important role of these alkenyl ether lipids and the interest plasmalogens
is currently attracting.
Biochemical investigations like RBC plasmalogen
levels and phytanic acid levels could not be done because of financial constraints.
Further biochemical studies showed high phytanic acid (9.2; n < 5.28 [micro]mol/L) and low plasmalogen
(3.2; n > 6.6) levels.
Engelmann, "Delayed oxidative degradation of polyunsaturated diacyl phospholipids in the presence of plasmalogen
phospholipids in vitro," Biochemical Journal, vol.
Ether glycerolipid (plasmalogen
) biosynthesis: DHAP-ATPase, alkyl-DHAP synthase 4.
Relative high percentages of the plasmalogen
derivatives 16:0DMA and 18:0DMA were also detected.
Analyses of the fatty acid pattern of membrane phospholipids and plasmalogen
of human spermatozoa have demonstrated significant levels of polyunsaturated acids.
Peripheral nervous system plasmalogens
regulate Schwann cell differentiation and myelination.
Overall, cells treated with 10 [micro]M MEHP showed significantly higher levels of all glycerolipids (FA, MG, DG), PC, PS, phosphatidylserine plasmalogens
(PS-P), and phosphatidic acid plasmalogens
(PA-P) than cells treated with 0.1 [micro]M MEHP or controls showed.
These products are highly reactive and will oxidize plasmalogens
, which are enriched in lung and surfactant, to form chlorinated lipids (Cl-lipids), 2-chloropalmitaldehyde and 2-chlorostearalddehyde.
Ishikawa et al., "Myo-inositol treatment increases serum plasmalogens
and decreases small dense LDL, particularly in hyperlipidemic subjects with metabolic syndrome," Journal of Nutritional Science and Vitaminology (Tokyo), vol.
Juaneda et al., "Red blood cell plasmalogens
and docosahexaenoic acid are independently reduced in primary open-angle glaucoma," Experimental Eye Research, vol.