platelet-activating factor

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platelet-activating factor

[¦plāt·lət ′ak·tə‚vād·iŋ ‚fak·tər]
(immunology)
A phospholipid released by leukocytes that causes aggregation of platelets and other effects, such as an increase in vascular permeability and bronchoconstriction. Abbreviated PAF.
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Effects of the platelet activating factor on the proliferation and IgE secretion by U-266BL human myetoma cells.
2,4) Moreover P gingivalis LPS, through the induction in platelet activating factor (PAF) lipid messenger generation, has been shown to exert a detrimental effect on the synthesis of salivary mucin, (4) thus weakening the protective performance of the saliva-derived oral mucosal coating that constitutes the pre-epithelial element of oral mucosal defense.
documented that ginkgo extract is a potent inhibitor of platelet activating factor.
Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts.
TABLE 54 WORLDWIDE MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF PLATELET ACTIVATING FACTOR RECEPTOR ANTAGONISTS, 2009 (%) 78
Identification of the G994T missense mutation in exon 9 of the plasma platelet activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men.
58,63) This process leads to an increase in circulating tissue levels of various cytokines, (177-180) leukotrienes, (181) thromboxanes, (182) platelet activating factor, (183) complement components, (184) elastases, and other enzymes, (185) and it causes the formation of additional ROS.