It is important to have in mind that the approach to a patient with cheilitis includes, apart from dermatologic conditions, other related diseases such as some granulomatous diseases (Crohn's disease, sarcoidosis and Melkersson-Rosenthal syndrome), nutritional deficiencies, and gastrointestinal diseases (e.g., celiac disease, Plummer-Vinson syndrome
) (Table 4).
The development of hypopharyngeal cancers in the post-cricoid area in women in the age group of 30 to 50 years without a history of tobacco or alcohol use was associated with Plummer-Vinson syndrome
, also termed as Paterson-Brown-Kelly syndrome.
de Souza, "A case of plummer-vinson syndrome
esophageal web dysphagia treated by dilatation with cuffed endotracheal tube," International Journal of Head and Neck Surgery, vol.
Thus in the Plummer-Vinson syndrome
, a strong tendency for cancer development is found in the atrophic mucosa of the digestive tract.