polyadenylation

(redirected from Polyadenylate)
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polyadenylation

[‚päl·ē·ə‚den·ə′lā·shən]
(cell and molecular biology)
The addition of adenine nucleotides to the 3′ end of messenger ribonucleic acid molecules during posttranscriptional modification.
References in periodicals archive ?
The human HuR/ELAVl is located on chromosome 19 at position 19p13.2 [22] and encodes a 32 kD protein, which binds to mRNA targets via three highly conserved RNA-binding domains connected by a short-hinge region, belonging to the RNA recognition motif (RRM) superfamily [23]; RRM-1 and RRM-2 both bind to elements rich in adenosine/uridine (AU-rich elements, ARE), and RRM-3 binds to the polyadenylate tail of rapidly degrading mRNAs [24].
[3] The PABN1 gene, also known as PABP2, encoding the polyadenylate binding protein nuclear 1, has a polyalanine tract in the N-terminal end.
Anderson, "A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells," Cell, vol.