polyadenylation


Also found in: Medical, Wikipedia.

polyadenylation

[‚päl·ē·ə‚den·ə′lā·shən]
(cell and molecular biology)
The addition of adenine nucleotides to the 3′ end of messenger ribonucleic acid molecules during posttranscriptional modification.
References in periodicals archive ?
Its transcriptional cassette merges multi-factorial modifications to the liver-specific promoter module, FVIII transgene, synthetic polyadenylation signal and vector backbone sequence.
One polyadenylation signal (AATAAA) was present 14 nucleotides upstream of the poly(A) tail in both PTGES2a and PTGES2b genes (NCBI accession number: KY132103 and KY132104).
The SB-525 transcriptional cassette incorporates multi-factorial modifications to the liver-specific promoter module, FVIII transgene, synthetic polyadenylation signal and vector backbone sequence.
Comparative analysis of protein synthesis, transcription and cytoplasmic polyadenylation of mRNA during maturation of bovine oocytes in vitro.
For the protection of the 3' end against degradation by exonucleases and the export of mature mRNA to the cytoplasmic environment, nuclear polyadenylation is a crucial step (17).
The results of TopHat included all alternative splicing information, which was classified as skipped exon (SE), alternative 5' splicing site, alternative 3' splicing site, retained intron (RI), mutually exclusive exon, alternative promoter, alternative polyadenylation. The results are shown in Figure 1b.
Several additional DNA sequences flanking the 4qter-DRs are essential for disease development, including the simple sequence length polymorphism proximal to D4Z4 and the distal polyadenylation signal (PAS, ATTAAA) for the DUX4 transcript.[3],[4] Present pathogenic models were proposed to correlate with chromatin relaxation on D4Z4 contraction.
Structurally, the avian [mu]-opioid receptor messenger RNA (mRNA) species were complex, displaying differential splicing, alternative stop codons, and multiple polyadenylation signals.
These polycistronic RNAs are ultimately processed into individual molecules through the addition of a Spliced Leader [SL], a common miniexon sequence present in all the mature mRNAs of trypanosomatids, to the 5' end and a poly [A] tail to the 3' end, processes known as trans-splicing and polyadenylation, respectively [8].
Others are involved in important processes at the RNA level, including ribosome binding, mRNA processing (splicing, editing, polyadenylation) and transcription termination.
Notably, no conserved polyadenylation signal similar to bamboo mosaic virus and PVX was detected in the 3' UTR of AltMV [28].