Polycythemia


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Related to Polycythemia: polycythemia vera, secondary polycythemia

polycythemia

(pŏl'ēsīthē`mēə), condition characterized by an increase in the production of red blood cells, or erythrocytes, in the blood. Primary polycythemia, also called erythremia, or polycythemia vera, is a chronic, progressive disease, most common in middle-aged men. It is characterized by overgrowth of the bone marrow, abnormally increased red blood cell production, and an enlarged spleen. Symptoms, include headache, inability to concentrate, and pain in the fingers and toes. There is a danger of blood clotting or hemorrhage (see thrombosisthrombosis
, obstruction of an artery or vein by a blood clot (thrombus). Arterial thrombosis is generally more serious because the supply of oxygen and nutrition to an area of the body is halted.
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). Primary polycythemia is treated by radiation, periodic removal of some blood (phlebotomy), or chemotherapy with antimetabolite drugs, e.g., CytoxanCytoxan
, trade name for the drug cyclophosphamide, used to inhibit growth of tumors and rapidly proliferating cells. It is used in the treatment of leukemia, Hodgkin's disease, and lymphosarcoma and other solid tumors.
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. In secondary polycythemia, or erythrocytosis, the proliferation of red blood cells results from the body's attempt to compensate for other conditions, such as prolonged lack of oxygen at high altitudes or chronic lung or heart insufficiency. Certain tumors are also associated with increased red blood cell production. In secondary polycythemia the treatment is directed toward the underlying cause.

Polycythemia

 

an increase in the total quantity of blood in the human body. A distinction is made between polycythemia vera, in which the increase in erythrocytes, up to 8–10 million in 1cu mm of blood, is greater than the increase in the total volume of blood plasma, and hypervolemia, which is characterized chiefly by an increase in the volume of plasma. The latter may be of cardiac origin or may be due to water retention in the vascular system after copious drinking. The normal ratio of the volume of blood cells to that of plasma is 45:55.


Polycythemia

 

an increase in the number of erythrocytes in the blood. Spurious, or relative, polycythemia results from a reduction in the volume of blood plasma and is caused by loss of fluid, as from heavy perspiration or from diarrhea. Secondary polycythemia is characterized by an absolute increase in the number of erythrocytes, as with oxygen deficiency in the mountains, heart disease, or pulmonary emphysema. Secondary polycythemia accompanied by an increase in the volume of blood plasma is called polycythemia vera, or erythremia.

polycythemia

[‚päl·i‚sī′thē·mē·ə]
(medicine)
A condition characterized by an increased number of erythrocytes in the circulation.
References in periodicals archive ?
Similarly, although hypertension and polycythemia associated with RL are seen in adults, this association has been first reported in a pediatric case (8).
JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis.
Fliedner et al., "Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma- polycythemia," Journal of Molecular Medicine, vol.
Polycythemia vera (PV) is a myeloproliferative disorder with an increased risk of both arterial and venous thromboembolism including acute myocardial infarction through increased risk for clot formation [5].
Pereira et al., "Risk factors for non-melanoma skin cancer in patients with essential thrombocythemia and polycythemia vera," European Journal of Haematology, vol.
Due to the polycythemia having no obvious etiology, a bone marrow aspiration and biopsy were performed (Figures 1(a) and 1(b)).
Pathogenesis of hypocalcemia in neonatal polycythemia. Med Hypotheses 1989 Sep; 30(1):49-50.
Symptomatic secondary polycythemia induced by anti-VEGF therapy for the treatment of metastatic renal cell carcinoma: A case series and review.
In CMPN common disorders include polycythemia vera (PV), essential thrombocythemia (ET), idiopathic myelofibrosis (IMF) and chronic myeloid leukemia (CML).
Then, the rats were equally divided into four groups: Control group, curcumin-treated group, EPO-induced polycythemia group, and curcumin + EPO-induced polycythemia group.
Unlike TTTS, twin anemia polycythemia sequence (TAPS) does not involve a fluid shift.