. Curr Treat Options Oncol 2018; 19(2):12(2):12.
(PV) is a myeloproliferative disorder with an increased risk of both arterial and venous thromboembolism including acute myocardial infarction through increased risk for clot formation .
Pereira et al., "Risk factors for non-melanoma skin cancer in patients with essential thrombocythemia and polycythemia vera
," European Journal of Haematology, vol.
A 55-year-old woman had been diagnosed as having polycythemia vera
in 2005 and followed up by a hematologist at another hospital.
(2.) Scott LM, TongW, Levine RL, etal.JAK2 exon 12 mutations in polycythemia vera
and idiopathic erythrocytosis.
from CHOP, along with Rivella and colleagues, investigated in the current study how minihepcidins affected beta-thalassemia and polycythemia vera
(PV) in mice separately engineered to model each human disease.
Treatment of polycythemia vera
: use of 32P alone or with a maintenance therapy using Hydroxyurea in 461 patients aged more than 65 years.
As model genes, the researchers used JAK2, a gene that when mutated causes a bone marrow disorder known as polycythemia vera
; SERP1NA1, a gene that when mutated causes alpha 1-antitrypsin deficiency, an inherited disorder that may cause lung and liver disease; and AAVS1, a gene that's been recently discovered to be a "safe harbor" in the human genome for inserting foreign genes.
A JAK2 mutation also shows up in people with polycythemia vera
, a disease marked by a high red blood cell count.
Nine of these 13 cases had a prothrombotic state like myeloproliferative disorder, Polycythemia vera
, protein C and protein S deficiency.
As for his polycythemia, the V617F mutation in the JAK2 gene was negative and therefore polycythemia vera
was ruled out.
Increased [Hb] may indicate erythrocytosis due to smoking (7) or in response to hypoxia at high altitudes (8), polycythemia vera
(9), congenital heart disease (10), severe chronic obstructive pulmonary disease (11), or severe dehydration (12).