6 In polydactyly
, males are more commonly affected then the females.
That's because only those cats showing the trait carry the gene, or unit of hereditary material, for polydactyly
Sixty percent to 80% of fetuses with trisomy 13 have postaxial polydactyly
of either the hands or the feet.
While postaxial polydactyly
remains the most commonly described limb anomaly in affected individuals, isolated reports of other limb anomalies, including thumb hypoplasia, oligodactyly and split hand malformation (SHM), have been documented in the literature.
Association of thumb hypoplasia/aplasia with polydactyly
has not been much elucidated and is an interesting question for further studies.
1,5 In the patients with JS, some studies determined that the respective frequency of anomalies as tongue protusion, tongue tumours, polydactyly
, kidney anomalies, megalocephaly, microcephaly, ocular coloboma, retinal dystrophy, esophageal reflux, pectus excavatum, hepatic anomalies, hydrocephaly, bradycardia, cardiac failure, cerebral palsy, asthma, webbed feet and cleft lip.
With the exception of the two individuals with polydactyly
, both with 5 digits on a forelimb (probably as result of the process of regeneration after the marking by toe clipping made in previous seasons 2004 and 2005), no morphological abnormalities in newts were observed.
The impact of lmbr1 on chicken polydactyly
was reported in several studies (Warren, 1944; Tickle, 1975; Tickle, 1981; Huang et al.
Hands and feet should be evaluated to rule out polydactyly
and talipes (deformities of the feet and ankles).
The principal manifestations are rod-cone dystrophy (Retinitis pigmentosa), postaxial polydactyly
, central obesity, mental retardation, hypogonadism and renal dysfunction.
The clinical spectrum of manifestations is broad, but can be summarised as craniofacial abnormalities including cleft palate and microcephaly, postaxial polydactyly
and syndactyly of the toes, cardiac defects, pyloric stenosis, aganglionosis of the colon and ambiguous genitalia.
There was a history of second/third toes syndactyly in a maternal aunt and polydactyly
(postaxial type B in hands only) in a fourth degree relative (Fig.