polyene

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polyene

[′päl·ē‚ēn]
(organic chemistry)
Compound containing many double bonds, such as the carotenoids.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterol.
Physical and chemical analysis of commercial nystatin/Analises fisico-quimicas da nistatina comercial
Although numerous polyene antibiotics have been isolated, only amphotericin B is used systemically.
Synthesis and evaluation of antimicrobial activity of novel 1,3,4-oxadiazole derivatives
A major group of drugs that have been approved for the therapy of systemic fungal infections are polyene antibiotics. Amphotericin B (AmB), one of the pofyene antibiotics, has been used to treat serious systemic fungal infections by binding to sterols such as ergosterol in fungal cells membrane, and is believed to form pores in the membrane and create a transmembrane ion-channel.
In silico design and selection of anti-fungal AmB-polyene-analog lead molecules by Virtual screening method

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