polyene
(redirected from Polyene antibiotics)Also found in: Dictionary, Medical.
polyene
[′päl·ē‚ēn] (organic chemistry)
Compound containing many double bonds, such as the carotenoids.
Also found in: Dictionary, Medical.
References in periodicals archive
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Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterol.
Although numerous polyene antibiotics have been isolated, only amphotericin B is used systemically.
A major group of drugs that have been approved for the therapy of systemic fungal infections are polyene antibiotics. Amphotericin B (AmB), one of the pofyene antibiotics, has been used to treat serious systemic fungal infections by binding to sterols such as ergosterol in fungal cells membrane, and is believed to form pores in the membrane and create a transmembrane ion-channel.
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