Precancer


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Related to Precancer: precancerous, precancerous lesion

Precancer

 

pathological changes that precede the development of a malignant tumor.

The concept of “precancer” was first formulated with regard to skin cancer, which is the most accessible to clinical observation. Later, precancer was diagnosed in the lower lip, breasts, cervix of the uterus, and stomach. Research in experimental oncology has demonstrated that precancerous conditions differing in clinical manifestations represent the same basic pathological process with the same definite pattern.

There are three stages of precancer generally distinguished in Soviet oncology. In the stage of uneven diffuse hyperplasia, the tissue retains its normal structure, but the number of its structural elements, such as cells and fibers, increases. In the stage of focal proliferation, the total mass of multiplying cells contains areas, or foci, in which the cells divide with unusual rapidity. In the comparatively benign tumor stage the foci of multiplying cells steadily cease to resemble the original tissue and become increasingly isolated but do not exhibit a tendency toward invasive growth—that is, growth into and destruction of healthy tissue. The first stage is not yet precancer in the strict sense of the word. The second stage is the most characteristic stage of a precancer. The third stage is not essential, since the cancer can bypass it and continue developing. A precancer can regress or cease developing for a long time.

REFERENCE

Shabad, L. M. Predrak v eksperimental’no-morfologicheskom aspekte. Moscow, 1967.
References in periodicals archive ?
As women with HIV live longer because of antiretroviral therapy, there is a growing need to prevent cervical cancer and to detect precancer cervical changes early.
The researchers looked at precancer cervical lesions instead.
Inovio Pharmaceuticals has closed an agreement providing ApolloBio with exclusive rights to develop, manufacture and commercialize VGX-3100, Inovio's DNA immunotherapy product designed to treat precancers caused by human papillomavirus (HPV), within mainland China, Hong Kong, Macao, and Taiwan.
Sensitivity was 84.0% overall (76.6% for precancer and 86.9% for cancer), specificity was 97.3% overall (97.3% and 97.3%), and area under the receiver operating characteristic curve was 0.87 overall (0.84 and 0.88).
The Huang group has conducted several studies on cervical precancer detection by using Raman spectroscopy in vivo [55, 56].
Effective screening and treatment for precancer of the cervix are a secondary prevention strategy that has been implemented globally to prevent cervical cancer.
Women who receive human papillomavirus (HPV) testing in addition to a pap smear receive a faster, more complete diagnosis of possible cervical precancer, according to a study of more than 450,000 women by Queen Mary University of London (OMUL) and the University of New Mexico Comprehensive Cancer Center.
([22,24,25]) The changes in the lipid peroxidation processes in the saliva of patients with oral cavity precancer and cancer are described by the example of MDA.
AK is considered a precancer because if left alone, it could develop into a skin cancer, most often the second most common form of the disease, squamous cell carcinoma (SCC).
The CE course, Oral Precancer and the HPV Connection, discusses early intervention, precancer, and three levels of prevention; patient perceptions of current and oral cancer screening protocols; HPV's connection to oral cancer; lifestyle risk factors; and HPV vaccine controversies.
* Actinic keratosis is the most common precancer; it affects more than 58 million Americans.
A pathology exam revealed that 58% of the patients did not have high-grade precancer or cancer.