This is the first study to describe the clinical course of ENL in a clinic where patients can be treated with thalidomide and prednisolone
in a non-endemic region.
During a 2-hour period at the emergency department, 100-mm visual analog scale (VAS) pain scores at rest declined by 6.54 mm/hour with indomethacin and by 5.05 mm/hour with prednisolone
, and with activity, the declines were 11.69 mm/hour and 11.38 mm/hour, respectively.
Conclusion: The frequency of acceptable outcome of combination of low dose oral Prednisolone
with oral propranolol for the treatment of infantile hemangioma is higher.
The investigators found that the risk of preterm birth increased with every cumulative milligram of prednisolone
(OR, 1.08; 95% CI, 1.021.15; P less than .01).
We followed the patients until 6 months after discontinuation of prednisolone
. In both cases there were no (further) recurrences or relapse.
After carrying out different investigatory meetings with the player and hearing all his defenses, the members of preliminary commission together with the sports medicine specialists, pharmacologists, and ophthalmologists studied all medical documents and finally accepted the player's claim for the improper and excessive (intensive) use of prednisolone
1% drops (2 drops of prednisolone
for each eye up to 4 times during a day) for 6 consecutive months before the sampling.
Patients were randomly assigned to four groups, each receiving two treatments: prednisolone
and pentoxifylline, prednisolone
and placebo, pentoxifylline and placebo, or both placebo.
From weeks 29 to 60, prednisolone
(2.2 mg/kg PO q12h) was administered as a palliative treatment.
Cyclosporine 50mg/day added along with prednisolone
30mg and dapsone 25mg and given for 18 days.
Clinical markers of response to treatment, at monthly intervals Baseline Month 1 Month 2 Average prednisolone
dose (mg) 50 15 35 C-reactive protein (mg/l) 29 5 <5 Erythrocyte sedimentation 25 2 2 rate (mm/h) VAS chest wall pain 80 30 0 VAS ear pain 85 45 15 Swollen joint count 14 4 12 Tender joint count 47 8 53 Functional score (HAQ) 3.125 2.25 3.125 Month 3 Month 4 Month 5 Average prednisolone
dose (mg) 20 20 50 C-reactive protein (mg/l) <5 <5 <5 Erythrocyte sedimentation 5 4 5 rate (mm/h) VAS chest wall pain 0 20 50 VAS ear pain 30 20 20 Swollen joint count 8 4 1 Tender joint count 24 8 1 Functional score (HAQ) 2.25 2.13 2.57 VAS, visual analogue scale; HAQ, Health Assessment Questionnaire.
For the 12 months ending 30 September 2014, Prednisolone
Sodium Phosphate Orally Disintegrating Tablets, 10 mg, 15 mg, and 30 mg, had US sales of about USD19.9m, according to IMS Health.
In our study, only 1 patient received such therapy, 33-year-old female patient who was on multiple systemic immunosuppressive agents including prednisolone
, MMF, azathioprine, and adalimumab.