lymphoma

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lymphoma,

a cancer of the tissue of the lymphatic systemlymphatic system
, network of vessels carrying lymph, or tissue-cleansing fluid, from the tissues into the veins of the circulatory system. The lymphatic system functions along with the circulatory system in absorbing nutrients from the small intestines.
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. There are two categories of lymphomas. One type is termed Hodgkin's diseaseHodgkin's disease,
a type of cancer of the lymphatic system. First identified in 1832 in England by Thomas Hodgkin, it is a type of malignant lymphoma. Incidence peaks in young adults and the elderly.
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, the other, non-Hodgkin's lymphoma (see lymphoma, non-Hodgkin'slymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
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). See also neoplasmneoplasm
or tumor,
tissue composed of cells that grow in an abnormal way. Normal tissue is growth-limited, i.e., cell reproduction is equal to cell death. Feedback controls limit cell division after a certain number of cells have developed, allowing for tissue repair
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.

lymphoma

[lim′fō·mə]
(medicine)
Any neoplasm, usually malignant, of the lymphoid tissues.
References in periodicals archive ?
Pericardial primary effusion lymphoma. AIDS Read, 2007, 17, 250-252.
Primary effusion lymphoma cells lack T-cell-associated antigen expression, although exceedingly rare cases of PEL of T-cell lineage have been reported.
Primary effusion lymphoma cells typically display a "null" lymphocyte phenotype: CD45 is expressed, but common pan-B-cell (CD19, CD20, CD79a, surface immunoglobulins) and T-cell (CD3, CD4, CD8) markers are absent.
Primary effusion lymphoma and EC-PEL are rare accounting for less than 5% of HIV-related lymphomas.
Both the B-cell antigen expression and lack of aberrant T-cell expression in pyothorax-associated lymphoma contrast with that observed in primary effusion lymphoma. Pyothorax-associated lymphoma has been shown to have a postgerminal center B-cell phenotype ([CD10.sup.-], [Bcl6.sup.-], [MUM1.sup.+], [CD138.sup.+] phenotype).
Human Immunodeficiency Virus-Associated Gastrointestinal Tract Neoplasms in Southern Africa Mesenchymal Epstein-Barr virus-associated smooth muscle tumors Kaposi sarcoma Lymphoid Hodgkin lymphoma Non-Hodgkin lymphoma Burkitt lymphoma Diffuse large B-cell lymphoma, not otherwise specified Mucosa-associated lymphoid tissue lymphoma Plasmablastic lymphoma Posttransplant lymphoproliferative disorder Primary effusion lymphoma Epithelial Anal intraepithelial neoplasia/squamous cell carcinoma Table 2.
Notch1 and Mammalian Target of Rapamycin (mTOR) Target Expression in Plasmablastic Lymphoma (PBL), Primary Effusion Lymphoma (PEL), and Plasma Cell Myeloma (PCM) No.
Primary Effusion Lymphoma: [CD45.sup.+/-], [CD30.sup.+/-], [CD38.sup.+/-], [CD138.sup.+/-], EMA+/-, [CD19.sup.-], [CD20.sup.-], [CD79a.sup.-], [CD3.sup.-/+], BCL6-, HHV8/KSHV+, EBV+/-, IGH and IGL gene rearrangements.
Primary effusion lymphoma or body cavity lymphoma is an LBCL universally associated with KSHV/HHV8, usually presenting as a serous effusion without detectable tumor masses.
Primary effusion lymphoma (PEL) has been recently identified as a distinct subtype of non-Hodgkin lymphoma associated with infection of the neoplastic lymphoid cells by the Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (HHV-8).[1,2] Primary effusion lymphoma has characteristic clinicopathologic features, including initial presentation as a lymphomatous effusion usually in the absence of a detectable tumor mass, occurs mostly in human immunodeficiency virus (HIV)-positive men, and has a morphologic structure that bridges large cell immunoblastic and anaplastic large cell lymphoma (ALCL).[1,2] Neoplastic lymphoid cells are B cells with a peculiar phenotype.
These three HHV8-associated NHL were all T-cell primary effusion lymphomas (two classic and one solid variant PEL), although T-cell receptor rearrangement was demonstrated in only one of the three cases (33%).