caspase

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caspase

[′kas‚pās]
(cell and molecular biology)
Any of a family of intracellular proteins that mediate apoptosis.
References in periodicals archive ?
At the same time, these proteins recruit key molecules that are responsible for mediating the intracellular signal, among these, procaspase 8 and subsequent formation of the DISC complex [13-15, 35].
Primary antibodies for procaspase 3, caspase 8, caspase 9, CDK6, p53, and cleaved PARP were purchased from Cell Signaling Technology (Beverly, MA).
Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation.
IFN can also induce the synthesis of gene products that arrest the cell cycle such as p21 and thus block virus replication, or induce a pro-apoptotic state such as procaspases. IFN can induce the synthesis of proteins that are involved in the processing and presentation of virus proteins to [CD8.sup.+] cytotoxic T lymphocytes.
The mitochondria is the central regulator of the intrinsic pathway of apoptosis and that is accompanied by the release of procaspases, cytochrome c, apoptotic protease-activating factor 1 (Apaf-1), endonuclease G and apoptosis-inducing factor (Green 2000).