prodrug

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prodrug

[′prō‚drəg]
(physiology)
An inactive precursor of a drug that is activated via the body's metabolism.
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References in periodicals archive ?
CLX-106, a patented novel formulation of MMF conjugated to icosapentaenoic acid for the treatment of RRMS and psoriasis, has demonstrated a highly differentiated profile compared with other MMF prodrugs in development.
At the site of the tumour these so-called prodrugs are subsequently converted into powerful anti-cancer drugs through irradiation with light.
Biopharmaceutical company Biohaven Pharmaceutical Holding Company Ltd (NYSE:BHVN) reported on Wednesday the receipt of a Notice of Allowance from the US Patent and Trademark Office (USPTO) covering certain prodrugs of the glutamate modulating agent riluzole.
Keywords: Hydroxypropylcellulose, Mefenamic acid, Macromolecular prodrugs, Polysaccharides, Thermal analysis
The claims awarded in this patent reflect the highly innovative nature of the targeted prodrug technology embodied in Semafore's lead compound," said Ronald Henriksen, chief executive office of Semafore.
The enzyme only attaches to cancerous cells, so that when the prodrug is given it passes harmlessly through healthy tissue, targeting only a tumour.
Under terms of the agreement, Merck will contribute drug candidates to the collaboration and Metabasis will apply its liver targeting, HepDirect prodrug technology with the objective of identifying novel drugs for the treatment of the disease.
Medarex received its rights to Super-Leu-Dox (CPI-0004) through the acquisition of Corixa Corporation's Tumor Activated Prodrug (TAP) program.
The use of prodrugs has the following implications for therapeutic drug monitoring:
Ensysce prodrugs are contrasted from current and emerging opioid technologies in that they do not require an elaborate formulation to confer parenteral and nasal abuse-deterrence.
Five cell lines have been observed to produce the desired enzyme and are being further assessed with specific phytocannabinoid prodrugs.