Proenzyme


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proenzyme

[prō′en‚zīm]
(biochemistry)

Proenzyme

 

(also proferment, zymogen, preenzyme), an inactive precursor of enzymes. Proenzymes form during the biosynthesis of enzymes. They are converted into active enzymes following limited proteolysis. The fission of usually one of the peptide bonds of the proenzyme molecule, which results in a partial structural change in the molecule, leads to the formation of the enzyme’s active center. Many proteolytics that are present in animals and bacteria, as well as phospholipase, are synthesized as proenzymes. Typical proenzymes include pepsinogen, trypsinogen, and prothrombin. Proenzymes are biologically important because they inhibit premature enzymatic activity in those cells and tissues where there is enzyme biosynthesis.

References in periodicals archive ?
Phenoloxidase in larvae of Plodia interpunctella (Lepidoptera: Pyralidea): molecular cloning of the proenzyme cDNA and enzyme activity in larvae paralyzed and parasitized by Habrobracon hebetor (Hymenoptera: Braconidae).
In the present work we describe a convenient, rapid, and sensitive method for detection of BACE-1 activity in biological samples, based on immunocapture with a specific BACE-1--binding antibody and a sensitive 2-step detection method based on activation of an engineered proenzyme. The detection limit of this method corresponds to the activity of 0.02 [micro]L active recombinant BACE-1.
PRP is a solution for intravenous administration of a combination of two pancreatic proenzymes trypsinogen and chymotrypsinogen that seeks to prevent recurrence and metastasis from solid tumors.
The additional composition claims are a continuation from the original foundation patent in the U.S., and as a result, both method of treatment and composition claims now protects the Company's lead product candidate, PRP, a pharmaceutical composition consisting of two proenzymes, trypinsogen and chymotrypsinogen, for treating cancer.
Caspase is synthesized as an inactive proenzyme (zymogen) in living cells.
Three enzymes derived from pancreatic acinar cellsamylase, lipase and the proenzyme trypsinogen have been tested as biochemical markers of acute pancreatitis; and although elevated serum pancreatic enzymes support clinical diagnosis of acute pancreatitis, numerous reports however describe the lack of usefulness of serum enzyme levels to determine the prognosis in acute pancreatitis as well.
The proenzyme is secreted and autocatalytically activated after cleavage of the signal peptide.
Marmer, "Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin," The Journal of Biological Chemistry, vol.
Gareau et al., "Maintenance of caspase-3 proenzyme dormancy by an intrinsic 'safety catch' regulatory tripeptide," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
In studies of AML blasts, it has been shown that cases with much stronger positivity by FCM than by EC produce relatively more of the MPO proenzyme than active enzyme.
Cathepsins are also responsible for inhibition of the proteolytic function until the proenzyme reaches the lysosome (Cygler and Mort, 1997).
(2011) Group X secreted phospholipase [A.sub.2] proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells.