Local delivery of the progestin
with the LNG-IUS allows for a reduction of the delivered dose and mitigates side effects even as it uses a more potent progestin
Abnormal uterine bleeding: Because of their ability to inhibit bleeding, progestins
are often used to manage excessive or abnormal uterine bleeding (AUB).
In men, progestin
increases the contraceptive effectiveness of testosterone.
The labels will state that some of the studies found a threefold increased risk in VTEs associated with drospirenone-containing OCs, compared with those containing levonorgestrel or another progestin
, while others found no increased risk, according to the FDA statement.
in HT is included primarily to prevent buildup of the uterine lining.
In addition to the trials of estrogen alone and estrogen plus progestin
, other WHI trials are studying a low-fat eating pattern and calcium and vitamin D supplementation.
Some people have argued, however, that progestins
carry risks of their own that can offset the benefits of estrogen.
WASHINGTON--The Food and Drug Administration last month said that all manufacturers of drugs that contain estrogen or estrogen and progestin
for menopausal women must include a boxed warning on their labels that the drugs may slightly increase the risk of heart disease, strokes, blood clots and breast cancer.
allow the use of less testosterone and thereby reduce androgen-related side effects.
Andreas Daxenberger and his colleagues inserted implants of trenbolone acetate--an androgen--into the ears of 41 males and females and gave feed laced with melengestrol acetate, a progestin
, to another 12 females that had never been pregnant.
Over 60 percent of evaluable patients had a previous preterm birth at or below 32 weeks gestation; prior studies of progestins
to prevent preterm birth were comprised mainly of patients with prior preterm births at 34 weeks or greater.
The product is intended to help identify patients whom could potentially benefit from treatment with anti-progestins
including onapristone, an orally-administered, investigational type 1 progestin
receptor antagonist being developed by Arno.