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Related to Progestins: Progestogens



gestagens, a group of substances with properties of the female sex hormone, progesterone (the hormone of the corpus luteum), and of the products of its metabolism.

Progestin are found in the corpus luteum, the placenta, ovaries, adrenals, and blood of humans and other mammals. The male sex glands also contain a certain amount of progestins. They exert influence on the mucous membrane of the uterus during pregnancy, ensuring normal development of the embryo. Substances exhibiting progestin-like activity have been obtained by chemical synthesis. Some of them (progesterone, pregnin) are used in medicine.

References in periodicals archive ?
Local delivery of the progestin with the LNG-IUS allows for a reduction of the delivered dose and mitigates side effects even as it uses a more potent progestin than MPA.
Abnormal uterine bleeding: Because of their ability to inhibit bleeding, progestins are often used to manage excessive or abnormal uterine bleeding (AUB).
In men, progestin increases the contraceptive effectiveness of testosterone.
The labels will state that some of the studies found a threefold increased risk in VTEs associated with drospirenone-containing OCs, compared with those containing levonorgestrel or another progestin, while others found no increased risk, according to the FDA statement.
The progestin in HT is included primarily to prevent buildup of the uterine lining.
Some people have argued, however, that progestins carry risks of their own that can offset the benefits of estrogen.
WASHINGTON--The Food and Drug Administration last month said that all manufacturers of drugs that contain estrogen or estrogen and progestin for menopausal women must include a boxed warning on their labels that the drugs may slightly increase the risk of heart disease, strokes, blood clots and breast cancer.
Furthermore, progestins allow the use of less testosterone and thereby reduce androgen-related side effects.
Andreas Daxenberger and his colleagues inserted implants of trenbolone acetate--an androgen--into the ears of 41 males and females and gave feed laced with melengestrol acetate, a progestin, to another 12 females that had never been pregnant.
Over 60 percent of evaluable patients had a previous preterm birth at or below 32 weeks gestation; prior studies of progestins to prevent preterm birth were comprised mainly of patients with prior preterm births at 34 weeks or greater.
The product is intended to help identify patients whom could potentially benefit from treatment with anti-progestins including onapristone, an orally-administered, investigational type 1 progestin receptor antagonist being developed by Arno.

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