The current case of unexpected status epilepticus is thought to be specifically due to an error in the metabolic pathway of propylene glycol. In human adults, propylene glycol is estimated to be eliminated at ~45% by renal route and ~55% through hepatic metabolism through lactate and pyruvate [2, 16].
Developmental issues and age in both humans and rats may result in complications when using drugs or food containing propylene glycol [1, 3, 14, 21-23].
Toxicity in otherwise healthy humans and rodents of propylene glycol is based on accumulation and concentration.
The seizures were initiated after 300 [micro]L [+ or -] 50 [micro]L IP administration of resveratrol in a 40 : 60 propylene glycol/corn oil vehicle solution (equivalent to 0.52 g/kg of propylene glycol).
(1) issues in the metabolic pathway of propylene glycol including (i) missing enzymes for lactate and/or pyruvate breakdown, (ii) activation of the gluconeogenesis pathway, or (iii) toxicity secondary to lactic acidosis,
The current findings correlate with other rodent and human pathologies to propylene glycol. This report appears to be the first published case of unexpected status epilepticus due to an IP injection containing propylene glycol.
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