propylene glycol

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propylene glycol

[′prō·pə‚lēn ′glī‚kȯl]
(organic chemistry)
CH3CHOHCH2OH A viscous, colorless liquid, miscible with water, alcohol, and many solvents; boils at 188°C; used as a chemical intermediate, antifreeze, solvent, lubricant, plasticizer, and bactericide.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The current case of unexpected status epilepticus is thought to be specifically due to an error in the metabolic pathway of propylene glycol. In human adults, propylene glycol is estimated to be eliminated at ~45% by renal route and ~55% through hepatic metabolism through lactate and pyruvate [2, 16].
Developmental issues and age in both humans and rats may result in complications when using drugs or food containing propylene glycol [1, 3, 14, 21-23].
Toxicity in otherwise healthy humans and rodents of propylene glycol is based on accumulation and concentration.
The seizures were initiated after 300 [micro]L [+ or -] 50 [micro]L IP administration of resveratrol in a 40 : 60 propylene glycol/corn oil vehicle solution (equivalent to 0.52 g/kg of propylene glycol).
(1) issues in the metabolic pathway of propylene glycol including (i) missing enzymes for lactate and/or pyruvate breakdown, (ii) activation of the gluconeogenesis pathway, or (iii) toxicity secondary to lactic acidosis,
The current findings correlate with other rodent and human pathologies to propylene glycol. This report appears to be the first published case of unexpected status epilepticus due to an IP injection containing propylene glycol.
Allegaert, "Biochemical tolerance during low dose propylene glycol exposure in neonates: a formulation-controlled evaluation," DARU, Journal of Pharmaceutical Sciences, vol.
Farber, "Propylene glycol toxicity: A severe iatrogenic illness in ICU patients receiving IV benzodiazepines: a case series and prospective, observational pilot study," Chest, vol.
Lansdown, "Long-term toxicity of propylene glycol in rats," Food and Cosmetics Toxicology, vol.
Litchfield, "The toxicity, metabolism, and pharmacologic properties of propylene glycol 1,2-dinitrate," Toxicology and Applied Pharmacology, vol.
Habtemariam et al., "A prospective evaluation of propylene glycol clearance and accumulation during continuous-infusion lorazepam in critically ill patients," Journal of Intensive Care Medicine, vol.