Proteolysis

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proteolysis

[‚prōd·ē′äl·ə·səs]
(biochemistry)
Fragmentation of a protein molecule by addition of water to the peptide bonds.

Proteolysis

 

the hydrolysis of peptide bonds that is catalyzed by proteolytic enzymes. During proteolysis, intrinsic proteins that are undergoing the catabolic process, as well as food proteins, are split into amino acids. Proteolysis is important in the formation of enzymes, hormones, and biologically active peptides from their inactive precursors. In plants proteolysis takes part in the mobilization of the storage proteins of seeds during germination.

References in periodicals archive ?
The direct effect of myostatin on protein degradation and synthesis is less understood when compared to skeletal muscles.
Other protein degradation and modification enrichment groups were identified, primarily at 150 min.
A previous study showed that hUTP14a caused p53 protein degradation, indicating its oncogenic potential.
The autophagic-lysosomal system is a protein degradation system activated by cellular stress that mediates break-down of misfolded proteins.
Effects of addition of previously fermented juice prepared from alfalfa on fermentation quality and protein degradation of alfalfa silage.
The ubiquilin LN2 (UBQLN2) protein plays a role in the ubiquitin--proteasome pathway that is responsible for protein degradation.
Interestingly, when they are polyubiquitinylated via Lys-63 of ubiquitin, the substrates escape from UPS-dependent protein degradation leading to their stabilization.
We look forward to working with Merck to create novel drugs to address difficult targets, and we believe this alliance will maximize the value of Arvinas'very exciting and innovative protein degradation technology," said Manuel Litchman, president and chief executive officer of Arvinas.
Part III presents a few chapters on monocyte-macrophage differentiation and T lymphocytes, while part IV addresses a range of general disease-related topics including sepsis, lysosomal degradation, cancer sensitization, biliary cirrhosis, cardiovascular disease, fatty liver disease, UV radiation resistance, Huntingtin protein degradation, and Lewy body disease.
This causes a series of protein degradation cascades and oxidation, leading to widespread molecular damage and neuronal cell death.
Crude protein degradation kinetic parameters and ED of the vegetable protein sources are given in Table 3.