protein kinase


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Related to protein kinase: Protein kinase C, Protein kinase B

protein kinase

[¦prō‚tēn ′kī‚nās]
(biochemistry)
An enzyme that exerts regulatory effects on growth and malignant transformation by phosphorylating proteins.
References in periodicals archive ?
RNA viruses, like polio and influenza, rely on high mutation rates to optimize the chance of finding a mutation that will defeat protein kinase R.
The lesions may regress upon discontinuation of the protein kinase inhibitor; otherwise, they "relentlessly" continue to develop.
Claim one of the patent relates to the use of protein kinase N beta as a downstream target of the PI3 kinase pathway.
So, protein kinase D is good under normal conditions, when it's regulated appropriately.
Various indications can be found in earlier papers about the significant role of the allosteric cooperativity in ligand binding with protein kinase A.
Recombinant protein kinases, optimized for crystallization, will be produced and exclusively marketed by ProQinase, while CRELUX will continue to provide customers with crystallization and X-ray crystallography services.
Although the cellular target of Pb is still elusive, exposure to Pb activates protein kinase C (PKC) in several types of cells, such as astrocytes and neuronal cells in the brain (Costa 1998; Markovac and Goldstein 1988).
Polo-like kinase-1 (PLK1) was identified as the principal protein kinase that carried out B23 phosphorylation at this site, and these findings point to PLK1 as a very promising cancer drug target.
However, for understanding the inhibition mechanism as well as for rational design of the protein kinase bisubstrate inhibitors, it is necessary to evaluate the effectiveness of the interaction of these compounds with the enzyme not only on the IC50 level, but also on the level of the true dissociation constants.
Both R5 gp120 and X4 gp120 activate the MAP kinases p38 and c-Jun amino terminal kinase/stress-activated protein kinase (JNK/SAPK), though it is unclear whether a third member of the MAPK family, extracellular regulated kinase (ERK 1/2), is activated.
This report represents a new and unique way of stratifying and analyzing the global protein kinase drug pipeline in oncology towards personalized medicine.
DelveInsight's, Protein Kinase C Beta (PKC-Beta) Inhibitors- Pipeline Insights, 2015 Report covers the Protein Kinase C Beta (PKC-Beta) Inhibitors pipeline molecules at various stages of development like Pre-registration phase, clinical phases (Phase III, Phase II & Phase I), pre-clinical and discovery phases.

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