protein kinase

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Related to Protein kinases: Phosphatases

protein kinase

[¦prō‚tēn ′kī‚nās]
(biochemistry)
An enzyme that exerts regulatory effects on growth and malignant transformation by phosphorylating proteins.
References in periodicals archive ?
Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase.
Arrien proprietary Fragment-Field Design (FFD) Technology(TM) typically involves scaffold-based design strategy; extensively implemented by utilizing structural biology data inputs and to assist Medicinal Chemistry in early phase of lead-to-drug-lead identification process along with its target focused scaffold-like libraries to design new lead candidates within various families of protein kinase drug targets.
02 nM) EGF produced a significant increase in transformation response as well as in extracellular signal-regulated protein kinase (ERK), SRE, or AP-1 activation.
Over a third of all pharmaceutical drug development is presently focused on protein kinase inhibitory drugs, but we expect this to increase even more, since the vast majority of protein kinases have yet to be pursued as drug targets, and definition of the precise roles of different kinases in non-cancer-related diseases is still in its infancy.
Worley's team received another clue when they found that protein kinases also bind to Preso1.
Comparison of the substrate specificity of adenosine 3':5'-monophosphate- and guanosine 3':5'-monophosphate-dependent protein kinases.
CRELUX and ProQinase have entered into a joint agreement to supply customers with crystal-grade protein kinases and readily available kinase complex structures.
Since the advent of DNA cloning and sequencing in the mid 1970s it has become clear that a large family of protein kinases exists which mediates most signal transduction in the human cell.
has signed agreements with Bio-Connect BV and KinaseDetect ApS and appointed them distributors in which Carna Biosciences has granted Bio-Connect exclusive rights to sell protein kinases in Germany, the United Kingdom, France, The Netherlands, Belgium and Luxembourg, and has granted KinaseDetect exclusive rights to sell protein kinases in the Scandinavian countries (Denmark, Sweden, Norway and Finland).
The three companies will collaborate in searching low-molecular compounds that inhibit the activities of two different cancer-specific protein kinases possessed by OTS.

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