GEN-003 is a first-in-class, protein subunit
, therapeutic T cell vaccine intended to reduce recurrence and transmission of Herpes Simplex Virus type 2 (HSV-2).
Total seed storage protein profiles were measured by SDS gel electrophoresis of seed protein extracts at 15, 30, 45, and 60 DAF to determine whether the increases in protein concentration were due to enhancement of specific seed storage protein subunits
or to enhancement of all storage protein subunits
The molecular weights of the dissociated polypeptide were determined by using molecular weight pre-stained protein standards "Fermentas PageRulerTM, Sigma USA" containing 250, 130, 95, 72, 55, 36, 28, 17 and 11 kDa protein subunits
As many as 30% of paragangliomas can be caused by inheritance of mutations in protein subunits
of succinate dehydrogenase, a critical enzyme within complex II of the mitochondrial respiratory chain.
This type of acetylcholine receptor consists of multiple protein subunits
, which form an ion channel in the cell membrane, and, as the name implies, also binds to nicotine.
Chromatography instrument systems are moving toward modular designs that accommodate sophisticated user needs to mix and match modules for the purification of diverse proteins and protein subunits
But the shell is non-uniform and asymmetrical; uncertainty has remained about the exact number of proteins involved and how the hexagons of six protein subunits
and pentagons of five subunits are joined.
Recent data suggest that soy protein subunits
, particularly 7S, directly activiate LDL receptors in the human liver, thus providing a novel mechanism of plasma cholesterol reduction different from currently available diets and hypolipidemic drugs.
One of the main arguments was that the bacterial flagellar apparatus, consisting of quite a large number of proteins with different functions, could not have evolved because each of the protein subunits
could not have evolved separately.
We are investigating how the individual protein subunits
conform as they come off the intact complex," explains Leary.
Differential accumulation of soybean seed storage protein subunits
in response to sulfur and nitrogen nutritional sources.
One stage in this cycle is the virus particle or virion, which is characterized by intrinsic properties such as size, mass, chemical composition, nucleotide sequence of the genome, and amino acid sequence of protein subunits
, among others.