proteoglycan

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Related to Proteoglycans: fibronectin

proteoglycan

[‚prōd·ē·ō′glī·kən]
(biochemistry)
A high-molecular-weight polyanionic substance covalently linked by numerous heteropolysaccharide side chains to a polypeptide chain backbone.
References in periodicals archive ?
Insulin increases synthesis of mucopolysaccharides in the chondrocytes whereas it elevates synthesis of proteoglycans in the tumor cells obtained from the chondrosarcoma cells.
1) Multiple cytokines and pathways have been related to the aforementioned stressors, including TGFp, connecting tissue growth factor, HIF1a, and ECM proteoglycans.
Initially, the goal of the study was to understand how interactions between PTP sigma and chondroitin sulfate proteoglycans prevent axon growth.
Subsequently, 5-[micro]m-thick sections from the mid-sagittal plane of the PPT complex were stained with Safranin O to examine the BTJ proteoglycan profile and with hematoxylin & eosin (H&E) to examine the general morphology; the latter analysis included an assessment of the tendon collagen fibers under a polarized microscope (Nikon Eclipse 50i, Nikon Inc.
Heparan sulphate (HS) is a proteoglycan synthesized in the endothelial cells and found in the extracellular part of the plasma membrane.
Cutaneous wound healing: significance of proteoglycans in scar formation.
At a molecular level, OA is accompanied by the disruptive turnover of extracellular matrix (ECM) in the cartilage; catabolic changes in ECM are mediated not only by the secretion of inflammatory mediators but by the disorganization, fragmentation and eventual loss of collagen fibres and proteoglycans such as aggrecans (a multi-molecular complex of glycoproteins and GAGs).
21) Matrix collagen has a leaf-like structure with proteoglycans projecting from a central hyaluronic acid backbone.
The composition of this extracellular environment contains substances known as glycoproteins, mucopolysaccharides, glycosaminoglycans, proteoglycans, and collagen.
VEGF exists in the mouse primarily as three isoforms, VEGF 120, 164, and 188, that differ in their ability to bind heparan sulfate proteoglycans on the cell surface and in the extracellular matrix.
First, the company explained, the most important layer for skin health is the dermis, which is composed of a collagen/elastin fiber network embedded with various ground substances such as HA and proteoglycans.
It can degrade a variety of substrates, including gelatin, collagens type IV, V, XIV, a2-macroglobulin, elastin, vitronectin, and proteoglycans.