proteasome

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proteasome

[′prōd·ē·ə‚sōm]
(biochemistry)
A large proteolytic particle found in the cytoplasm and nucleus of all eukaryotic cells that is the site for degradation of most intracellular proteins.
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The human homologue of PcUCH-L5 appears to be associated with the proteosome and possibly involved in TG[beta] signaling [19].
molecular and Cellular biology, Sep 2003, Ataxin 3 interaction with Rad23 and valosin containing protein and its association with ubiquitin chain and the proteosome are consistant with a role in ubiquitin mediated proteolysis, vol.
Auxin hormone receptors have been characterized and selective degradation of transcription factors via the ubiqutin-26S proteosome pathway is known to result from hormone binding but there is currently little understanding of how hormone reception leads to that accelerated transcription factor degradation or how this, in turn, alters developmental physiology.
They cause DNA damage, proteosome degradation, as well as extracellular protein alteration.
ID Biomedical is a biotechnology company focused on the development of proprietary subunit vaccine products, including those based on its Proteosome platform intranasal adjuvant/delivery technology.
Faustman and her colleagues have found that, in an inbred strain of mice prone to diabetes, defects in a cellular structure called the proteosome can prevent female cells from chopping up proteins as required for antigen presentation.
Lewandowski, "Disruption of prooxidant and antioxidant systems with elevated expression of the ubiquitin proteosome system in the cachectic heart muscle of nude mice," Journal of Cachexia, Sarcopenia and Muscle, vol.
Studies using proteosome inhibitor bortezomib, monoclonal antibodies bevacizumab in combination with pemetrexed and cisplatin are ongoing.
Upon stimulation with TNF-[alpha] [36], I[kappa]B can be phosphorylated by IKK-[beta] and subsequently inducing its ubiquination and proteosome mediated degradation, allowing nuclear translocation of NF-[kappa]B and alteration of its target genes expression, such as intercellular adhesion molecule-1 (ICAM-1), VCAM-1, and HGF, and thus played a crucial role in the course of tissue injury and immune response.
MHC I proteins are also expressed on microglia following their activation by inflammatory stimuli, and they bind to peptides from the cytosolic proteosome in the endoplasmic reticulum (ER) where MHC I is synthesized (Figure 1).
The mechanisms by which TRAIL-resistance may be overcome include inhibition of mRNA synthesis (Chen et al., 2001), Akt signalling (Chen et al., 2001) and proteosome function (Christian et al., 2009).