prothrombin time


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Related to prothrombin time: prothrombin time test

prothrombin time

[prō′thräm·bən ‚tīm]
(pathology)
A one-stage clotting test based on the time required for clotting to occur after the addition of tissue thromboplastin and calcium to decalcified plasma.
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A prolonged aPTT in spite of normal prothrombin time indicates the deficiency of factors VIII (Haemophilia A and von Willebrand Disease), IX and XI.
In the third cohort of two patients, one had very high liver enzymes and prothrombin time and she died within 24 hours of hospitalisation.
Similarly, raised bilirubin level is considered as a sign of hepatic dysfunction.8-9 Modified Child-Turcotte-Pugh (MCTP) scoring system has scores for albumin, bilirubin, prothrombin time, ascites, and hepatic encephalopathy which are related to prognosis of stage.
As both Prothrombin time and Activated Partial Thromboplastin Time were deranged during hospital stay and at multiple times in the previous records, factor levels were sent.
Patients with normal platelet count also have lower level of bilirubin (12.8 [+ or -] 7.67 versus 17.7[+ or -] 11.4 [micro]mol/L, p < 0.001), higher level of albumin (40.0 [+ or -] 5.03 versus 38.4 [+ or -] 5.28 g/L, p < 0.001), and less prolonged prothrombin time (12.3 [+ or -] 1.65 versus 13.1 [+ or -] 1.65, p < 0.001).
When we included age, markers of inflammation (i.e., CRP), and renal (i.e., creatinine), circulatory (i.e., lactate), and hepatic dysfunction (i.e., bilirubin and prothrombin time), high GDF-15 was an independent predictor of ICU mortality in critically ill patients with an HR of 3.42 (95% CI 1.33-8.78, Table 3).
These were the activated Partial Thromboplastin Time (aPTT) test which measures the intrinsic pathway of blood coagulation and the Prothrombin Time (PT) test which monitors the tissue factor (extrinsic) pathway of clotting.
Prior to the APAP-induced hepatotoxicity experiments, blood was collected from the tail veins of all mice to analyze prothrombin time. All mice in the treatment groups were orally administered their treatments once daily for 7 days after which hepatotoxicity was induced by oral gavage of 2.5 g/kg BW of APAP (Figure 2).
Creatinine clearance was 21 mL/min, hemoglobin was 9.4 g/dL, and prothrombin time Quick value was 30%.
Coagulation studies at that time showed a prolonged prothrombin time of 18 seconds {normal 11.3-15.2} and a partial thromboplastin time (aPTT) within the normal range.
The prothrombin time (PT) and the activated partial thromboplastin time (APTT) are global coagulation tests used to assess the coagulation system in a clinical setting.
His coagulation profile was normal [platelet count: 2.6 lakhs/[mm.sup.3], bleeding time: 3 min and clotting time: 5 min, prothrombin time: 12 sec (control: 13 sec), and activated partial thromboplastin time: 34 sec (control: 32 sec)].

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