proximal convoluted tubule

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Related to Proximal tubule: loop of Henle, Distal tubule

proximal convoluted tubule

[′präk·sə·məl ‚kän·və′lüd·əd ′tüb‚yül]
(anatomy)
The convoluted portion of the vertebrate nephron lying between Bowman's capsule and the loop of Henle; functions in the resorption of sugar, sodium and chloride ions, and water.
References in periodicals archive ?
Plasma creatinine is a nonspecific biomarker of renal injury, so it is possible that a subset of patients developed increased plasma creatinine in the absence of proximal tubule cell damage.
Similar to the findings in proximal tubule cells, total cholesterol was significantly elevated in the hepatic cells of the exhausted group with respect to the control group (0.
Thus, there is strong evidence that the ATP-Na-K-ATPase transport system is profoundly affected and appears to be the metabolic basis for altered transport in the proximal tubule (44).
In proximal tubule cells, megalin, a 600-kDa transmembrane glycoprotein, interacts synergistically with cubulin as scavenger for the luminal uptake of a large number of proteins, including albumin (Verroust et al.
Crystals cause acute necrotic cell death in renal proximal tubule cells, but not in collecting tubule cells.
A serious limitation of these studies is that the critical effects of Cd (proteinuria resulting from renal proximal tubule damage) and Zn (decreased erythrocyte superoxide dismutase activity indicative of altered copper status) were not included as endpoints, and the haematological endpoints were not particularly sensitive.
As a model for P-gp, we used the immortalized human proximal tubule cell line HK-2, purchased from the American Type Cell Collection and cultured as previously reported (Romiti et al.
2]), a heavy metal, is known to induce nephrotoxicity in the kidney involving inflammation and necrosis of the proximal tubule cells.
8 kD) protein that is freely filtered at the glomerulus and avidly taken up and catabolized by the proximal tubule (Brenner 2004).
ornithine, lysine, and arginine) in the renal proximal tubule and the small intestine epithelia.
About 85% of all kidney cancers are renal cell carcinomas (adenocarcinomas) developing in the proximal tubule of the renal parenchyma.