Purkinje Cell

(redirected from Purkinje)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.

Purkinje cell

[pər′kin·jē ‚sel]
Any of the cells of the cerebral cortex with large, flask-shaped bodies forming a single cell layer between the molecular and granular layers.

Purkinje Cell


any one of numerous large neurons of the cerebellar cortex whose axons extend beyond the cortex; first described in 1837 by J. E. Purkinje.

Purkinje cells transmit the commands of the cerebellar cortex to its subordinate motor centers, the cerebellar and vestibular nuclei. In mammals and birds, the bodies of Purkinje cells are arranged in the cerebellar cortex in a single layer, called the gangliar, or Purkinje, layer. The Purkinje layer is located between the molecular layer, into which each Purkinje cell extends a dendrite, and the granular layer, through which the axon of a Purkinje cell passes into the white matter of the cerebellum. The flattened dendrite of a Purkinje cell has smooth branches of the first, second, and third orders and short branches (not more than 20 μ long) that are covered with spines. These branches come in contact with the axon endings of the granular cells of the cerebellar cortex; in a cat, for example, there are about 0.2 million synapses per dendrite. The smooth branches of a dendrite and the body of the Purkinje cell come in contact with a convoluted liana-like fiber (one per Purkinje cell) that enters the cerebellum from the inferior olivas and some other nuclei of the medulla oblongata. Both types of synapses are excitatory.

The inhibitory endings of Purkinje cells are formed by intercellular cortical neurons (basket, stellate, and Golgi cells); gamma-aminobutyric acid seems to be the mediator. The same mediator is probably secreted by the axon endings of Purkinje cells onto the neurons of the cerebellar and vestibular nuclei.

The dendrites of Purkinje cells have become progressively more complex and flattened in the course of vertebrate evolution; the total number of Purkinje cells has also increased, totaling 15–20 million in man.


References in periodicals archive ?
In most cases of PCA, the neurological symptom has stabilized by the time treatment is started, meaning that Purkinje cell damage and neuronal loss have most probably already occurred (5).
Dendritic alterations of cerebellar Purkinje neurons in postnatally lead-exposed kittens.
Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline.
Major arrhythmias caused by chronic chloroquine use have been related to a significant reduction in the cardiac rate, increases in the action potential duration and refractory period of Purkinje fibers (7).
Consider the pine needle-like extensions of granule neurons, which help memories form deep in the brain; the behemoth, feathery Purkinje neurons that coordinate body movements; and the twinkly stellate interneurons that help transmit visual signals.
Although zinc supplementation in one study did not mitigate alcohol-induced cerebellar Purkinje cell loss following developmental alcohol exposure (Chen et al.
Closer examination reveals a reflection from the posterior (inner) surface, first described by Purkinje (1823) and referred to as "P2" (Purkinje image II) here.
NGF receptor immunoreactivity which was developed in the 3 layers of the cerebellar cortex in adult rats was decreased in the neuropil of the molecular layer and in the cytoplasm of Purkinje neurons of rats of 24 months.
Effect of prenatal exposure to diclofenac sodium on Purkinje cell numbers in rat cerebellum: A stereological study.
Such thinking carries forth the abstractionist approach to cognitive processes of Newton, Kant, and Helmholtz that won out over the opposing phenomenological, nontransduction model of Goethe, Purkinje, and Hering.
Domestic suppliers include Beijing Beifenruili and Beijing Purkinje General.