pyridoxal phosphate

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pyridoxal phosphate

(pĭr'ĭdŏks`əl): see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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; vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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.
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pyridoxal phosphate

[‚pir·ə′däk·səl ′fä‚sfāt]
(biochemistry)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
* Patients with coronary artery disease have, on average, 34.2% lower levels of the bioactive form of B6 (pyridoxal 5'-phosphate) compared to those without heart problems, which may relate to its role in lowering homocysteine.
Vitamin [B.sub.6] and its derivative pyridoxal 5'-phosphate (PLP) are essential to over 100 enzymes, most of which are involved in protein metabolism.
GAD is a pyridoxal 5'-phosphate (PLP) dependent enzyme, which catalyzes the irreversible decarboxylation of L-glutamic acid to gamma-aminobutyric acid (GABA) and carbon dioxide.
[4] Nonstandard abbreviations: ALP, alkaline phosphatase; PLP, pyridoxal 5'-phosphate; PA, pyridoxic acid; HPP, hypophosphatasia; TNSALP, tissue-nonspecific isoenzyme of alkaline phosphatase; PPi, inorganic pyrophosphate.
Selhub, "Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status," Journal of Nutrition, vol.
Selhub, "Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation," Nutrition Reviews, vol.
Chronic alcoholics are often deficient in pyridoxal 5'-phosphate (vitamin [B.sub.6]), which is a necessary coenzyme for both ALT and ALT synthesis.
Each subunit tightly attaches to one molecule of pyridoxal 5'-phosphate. Secondary structures identified in the protein motif region, which is graphical represented as a split-barrel structure.
Pyridoxal 5'-phosphate (PLP) is an essential cofactor in all living systems and participates in catalysis by a wide diversity of enzymes including oxidoreductases, transferases, hydrolases, lyases, isomerases.
At the supplier level Pamlab LLC, developer and marketer of Metanx, reported earlier this year that a multicenter study, done in collaboration with Tulane University and published in The American Journal of Medicine, suggests that nutritional management of diabetic peripheral neuropathy (DPN) with L-methylfolate, methylcobalamin and pyridoxal 5'-phosphate, a prescription medical food dispensed and commercially known as Metanx, improves total symptoms and health-related quality of life.
Radiographic evidence of skeletal mineralization was associated with reduced plasma levels of pyridoxal 5'-phosphate and increased levels of parathyroid hormone, which was initially suppressed in all patients.
submitted a citizen petition to the US Food and Drug Administration (FDA), asserting that dietary supplements containing pyridoxal 5'-phosphate (P5P) "are adulterated and are being unlawfully marketed." P5P is vitamin B6's bioactive form.