Pyrrole

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pyrrole

[′pi‚rōl]
(organic chemistry)
C4H5N Water-insoluble, yellowish oil, with pungent taste; soluble in alcohol, ether, and dilute acids; boils at 130°C; polymerizes in light; used to make drugs.

Pyrrole

 

a heterocyclic compound; colorless liquid that darkens rapidly upon exposure to air. Melting point, — 23.42°C; boiling point, 130°C; density, 0.9698 g/cm3 at 20°C. Moderately soluble in water. Pyrrole is a very weak acid; it forms a salt with potassium or anhydrous caustic potash. It resinifies under the influence of acids, and it oxidizes readily. It hydrogenates with H2 over Ni at 200°C to pyrrolidine.

Pyrrole was first isolated from coal tar. It is produced commercially

by dry distillation of the ammonia salt of mucic acid or by passing a mixture of furan and NH3 over Al2O3 at 400°–450°C. The pyrrole nucleus is a structural fragment of porphyrin molecules. Pyrrole is used in the production of pyrrolidine and in the synthesis of pharmaceuticals—for example, the antiseptic Iodol (2,3,4,5-tetraiodopyrrole).

References in periodicals archive ?
From the experiments conducted, it appears that pyrrole, neonicotinoids, and spinosyns were the most effective compounds tested to control both C.
The results obtained above strongly suggest that the electrochemical oxidation of the pyrrole and 3,4-ethylenedioxythiophene monomers form their corresponding copolymers on the electrode surface.
During one of our current research programs involving experiments with nitrogen heterocycles, utilizing reactions under conditions of phase-transfer catalysis between triethyl-benzylammonium chloride (TEBAC) and a pyrrole ring, it was observed that the catalyst participated as an N-alkylating agent providing a benzylated product.
Chlorfenapyr is a member of a new class of chemicals--the pyrroles. The compound is a pro-insecticide, i.e.
Heterocyclic compounds, mainly pyrazines, pyridines, pyrroles and thiazoles, found in fried and roasted chicken are listed in Table 6.
En el caso de los pyrroles, especificamente del Chlorfenapyr, cuyo mecanismo de accion es en la fosforilacion oxidativa, que impide la sintesis de ATP (11), la intoxicacion pareceria irreversible, y por ello seria insuficiente el tratamiento sintomatico, pues podria terminar en la muerte del paciente cinco o siete dias despues de la ingesta, como en el caso de nuestra paciente.
At ICOS 16, Thompson will present work on novel diastereoselective complexation reactions that generate dipyrromethene helicates with > 99 percent selectivity, as well as novel methodology by which to prepare functionalized pyrroles. The latter project includes the use of new sulfur-based protecting groups and the application of studies that involve microwave technology.
Hepatic microsomal enzymes biotransform alkaloids into highly reactive pyrroles that act as powerful alkylating agents.
However, the aroma components of green tea consist mostly of nitrogenous compounds such as pyrazines and pyrroles.
Root-canaled (dead) and infected teeth have hundreds of different bacteria living in them and secrete powerful toxins such as skatoles, pyrroles, indoles, thioethers, and mercaptans into the body, which can block phosphorylases and inhibit ATP manufacturing in the mitochondria.
Nitrogen containing heterocycles, such as pyrroles, indoles and carbazoles have attracted considerable attention due to their wide applications in pharmaceuticals and synthetic chemistry.