Pyrrolidine


Also found in: Dictionary, Medical, Wikipedia.
Related to Pyrrolidine: piperazine, Triethylamine

Pyrrolidine

 

tetrahydropyrrole, a heterocyclic compound; a colorless liquid with an ammoniac odor. Boiling point, 87°–88°C; density, 0.8576 g/cm3 at 20°C. It fumes in air and dissolves freely in water. Pyrrolidine is a strong base; it is oxidized to γ-aminobutyric acid by chromic acid.

Pyrrolidine is prepared commercially by hydrogenation of pyrrole or succinimide. The pyrrolidine ring forms a structural molecular fragment of many biologically active substances, including proline, nicotine, cocaine, and certain other alkaloids. Pyrrolidine is used in fine organic synthesis.

References in periodicals archive ?
B inhibitor pyrrolidine dithiocarbamate (PDTC) were purchased separately from InvivoGen, Inc.
Snaith, Annulation of dihydroimidazoles: a 1,3dipolar cycloaddition route to pyrrolo[1,2a]imidazoles, pyrrolidines and pyrroles, J.
tuberculatum were isolated several amides, mainly bearing isobutyl, pyrrolidine, dihydropyridone and piperidine moieties (Navickiene et al.
The short inventory of antibiotics in the farm and poor veterinary emergency service, as a last resource, the use of a commercial antibiotic for parenteral application was contemplated; this contained 200 mg/mL of tetracycline in a pyrrolidine solution with a pH of 7.
Diclofenac pyrrolidine versus Ketoprofen for the relief of pain from episiotomy: A randomized controlled trial.
We stabilized iron oxide nanoparticles in an aqueous environment with poly-N-vinyl pyrrolidine through chemical bonds.
The first is on asymmetric synthesis of heterocycles containing only one heteroatom and is organized into chapters according to the size of the ring: azirdine, azetideine, pyrrolidine, piperidine, azepine and larger rings.
Objective: In this study, we investigated protective effects of pyrrolidine dithiocarbamate (PDTC), which is an antioxidant and nuclear factor kappa B (NF-[kappa]3) inhibitor, on nephropathy in diabetic rat model.
Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells.
The biochemical bone reabsorption marker known as plasma CTX8 allows dynamic assessment of the level of bone tissue remodeling based on analysis of carboxyterminal telopeptide fragments of type I collagen that result from osteoclastic (9) action occurring within the bone matrix on its crosslink-forming interlinking molecules, pyrrolidine (PYD) and deoxypyrrolidine (DPD).
A cinnamoyl pyrrolidine amide from Piper peepuloides.
Nicotine is an amine composed of pyridine and pyrrolidine rings (Trushin & Hecht, 1999).