Pyruvic Acid

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pyruvic acid

[pī′rü·vik ′as·əd]
(biochemistry)
Important intermediate in protein and carbohydrate metabolism; liquid with acetic-acid aroma; melts at 11.8°C; miscible with alcohol, ether, and water; used in biochemical research.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Pyruvic Acid

 

(α-ketopropionic acid), CH3COCOOH, a colorless liquid with a pungent odor. Melting point, 13.6°C; boiling point, 165°C. Pyruvic acid is miscible with water, ethanol, and ether in all proportions. Chemically, it behaves like ketones and carboxylic acids.

Pyruvic acid occurs in the cells of all organisms as a fundamental intermediate link in the metabolism of carbohydrates, proteins, and lipides. It accumulates in the organism as a result of various metabolic disorders, for example, vitamin-B1 deficiency. Pyruvic acid is a component in the manufacture of the pharmaceutical cinchophen. The term “pyruvate,” which in strict usage refers to the pyruvic-acid anion, CH3COCOO, is frequently used as a synonym for “pyruvic acid” in biochemical literature.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
This occurs via the key signaling pathways including focal adhesion, Pyruvate metabolism, and the MAPK, FoxO, and TNF signaling pathway.
The levels of alanine, aspartate, pyruvate, malic acid, and fumaric acid were upregulated by QSHY intervention, which suggested that QSHY intervened beta-alanine metabolism, alanine, aspartate, and glutamate metabolism, pyruvate metabolism, and citrate cycle that might be correlated to the therapeutic mechanism of QSHY (Figure 7).
Amino acids derived from pyruvate metabolism and the TCA cycle metabolites, such as alanine, phenylalanine, tyrosine, serine, glycine, valine, and leucine, increase by nitrogen depletion, whereas aspartate, arginine, glutamate, and glutamine decrease [10].
Jin et al., "Simultaneous steady-state and dynamic [sup.13]C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells," The Journal of Biological Chemistry, vol.
Metabolic gene network analysis clearly indicated that oxidative metabolism, such as oxidative phosphorylation, citric acid cycle, pyruvate metabolism, glycolysis, and purine metabolism, was upregulated in the muscle tissue but downregulated in the intramuscular tissue.
Many disorders caused by or associated with a disturbance in pyruvate metabolism have been reported (1, 2).
Lactic acid dehydrogenase (LDHA) encoding enzymes involved in pyruvate metabolism. Pyruvate metabolism was shown to be implicated in diabetes.
Pyruvate metabolism in the rat brain using 13C-labelled pyruvate and glucose has been investigated (Hassel, 2001; Gonzalez et al., 2005).
Holness, "The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: going round in circles?" Islets, vol.

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