quinidine

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Related to Quinidine gluconate: Quinidine sulfate, Quinaglute

quinidine

(kwĭn`ĭdēn'), heart muscle relaxant used to maintain regular heart rhythm patterns. It is an alkaloidalkaloid,
any of a class of organic compounds composed of carbon, hydrogen, nitrogen, and usually oxygen that are often derived from plants. Although the name means alkalilike, some alkaloids do not exhibit alkaline properties.
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 chemically similar to quininequinine
, white crystalline alkaloid with a bitter taste. Before the development of more effective synthetic drugs such as quinacrine, chloroquine, and primaquine, quinine was the specific agent in the treatment of malaria.
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 and, like quinine, occurs naturally in some species of cinchona trees. Quinidine slows the rate of blood flow in heart chambers and lowers the excitability of the muscle. Quinidine is a general relaxant of smooth muscle and acts as a dilator of larger blood vessels. It has also been used to reduce fever and to treat malaria. Synchronized electric shock has largely replaced quinidine as a method of establishing more normal heart rhythms.

quinidine

[′kwin·ə‚dēn]
(organic chemistry)
C20H24N2O2 A crystalline alkaloid that melts at 174-175°C (345-347°F) and that may be derived from the bark of cinchona; used as the salt in medicine. Also known as β-quinine.
References in periodicals archive ?
The following dosing recommendations for quinidine gluconate administration are provided for pharmacists and clinicians treating patients with severe or complicated malaria:
Quinidine gluconate intravenous should be administered in a monitored setting.
Quinidine gluconate for malaria is administered as an initial intravenous loading dose of 10 mg/kg salt (equivalent to 6.
An alternative regimen is an intravenous loading dose of 24 mg/kg quinidine salt (equivalent to 15 mg/kg quinidine base) infused over 4 hours, followed by a maintenance infusion of 12 mg/kg of quinidine gluconate salt (equivalent to 7.
Treatment of malaria in the United States with a continuous infusion of quinidine gluconate and exchange transfusion.