Quinoline


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quinoline

[′kwin·ə‚lēn]
(organic chemistry)
C9H7N Water-soluble, aromatic nitrogen compound; colorless, hygroscopic liquid; also soluble in alcohol, ether, and carbon disulfide; boils at 238°C; used in medicine and as a chemical intermediate. Also known as chinoline; leucoline; leukol.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Quinoline

 

(2,3-benzopyridine), a heterocyclic compound. Quinoline is a colorless liquid with a characteristic sweetish odor and a boiling point of 238°C.

It is poorly soluble in water and readily soluble in alcohol and ether. It is a weak base and with acids forms salts, such as C9H7N·HCl. With alkyl halides, it forms quinolinium tertiary salts. Quinoline is found in coal tar, from which it is extracted together with isoquinoline. Synthetic quinoline is obtained by the Skraup reaction (seeSKRAUP SYNTHESIS). Quinoline is used as a solvent for sulfur and phosphorus and in the decarboxylation of aromatic acids and other reactions. Many alkaloids, such as quinine and fagarine, and drugs, such as Atophan (cinchophen), Entero-Septol (iodochlorhydroxyquin), chloroquine, and primaquine, are derivatives of quinoline, as are several cyanine dyes and analytical reagents, such as 8-hydroxyquinoline.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
LIANG, "A new quinoline alkaloid from the roots of Dictamnus angustifolius," Chinese Journal of Natural Medicines, vol.
Al-Sha'alan, "Antimicrobial activity and spectral, magnetic and thermal studies of some transition metal complexes of a Schiff base hydrazone containing a quinoline moiety," Molecules, vol.
Introduction of Antimalarial Drugs with the Quinoline Scaffold
The simple reaction of the quinoline carboxylic acids with ruthenium(II) diphosphine precursor complex cis-[Ru[Cl.sub.2][(dppm).sub.2]] resulted in the products cis[Ru(quin)[(dppm).sub.2]]P[F.sub.6] (1) and cis-[Ru(kynu)[(dppm).sub.2]]P[F.sub.6] (2), Figure 1, by simple chlorido exchange under mild conditions.
It was reported that the C-N position of pyridine ring in indole and quinoline can be broken down by the microbe [12, 13].
Ferriprotoporphyrin IX, phospholipdis, and the antimalarials actions of quinoline drugs.
The result showed that the main components were phthalic acid, butyl hexyl ester (42.85%), hexanedioic acid, bis(2-ethylhexyl) ester (5.22%), phthalic acid, 2ethylhexyl hexyl ester (13.96%), 2,6,10,14, 18,22tetracosahexaene, 2,6,10, 15, 19,23-hexamethyl-, (allE)-(3.13%), 1H-indole, 1-methyl-2- phenyl(1.07%), 2-amino-4-hydroxy-6,8-dimethyl-7 (8H)-pteridinone (11.69%), benzo[h] quinoline, 2,4dimethyl-(1.43%), 2,4,6-cyclo-heptatrien-1-one, 3,5-bis-trimethylsilyl- (2.50%), 3,3,7,11-tetramethyltricyclo [5.4.0.0(4,11)]undecan-1-ol-(1.43%), cyclohexane, 1,1,2-trimethyl-3,5- bis(1-methylethenyl)-, (2[+ or -],32,52)-(16.73%).
The Southampton Seven are: Tetrazine (E102), Quinoline yellow (104), Sunset yellow (110), Carmoisine (E122), Ponceau 4R (E124), Allura red (E129), and the preservative Sodium Benzoate (E211).
Nine monoterpenoid indole alkaloids; naucletine (1), angustidine (2), nauclefine (3), angustine (4), naucline (5), angustoline (6), harmane (7), 3,14-dihydroangustoline (8), strictosamide (9) and one quinoline alkaloid glycoside; pumiloside (10) from Nauclea officinalis were tested for cholinesterase inhibitory activity.