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The win made it a perfect 10 on home soil for the Quins in the Principality Premiership this season and moves them to within a point of leaders Merthyr.
Richard Bloomfield and Dylan Morgans scored for the Quins, with both tries converted by Steffan Marshall, who also kicked two penalties.
Julien Dumora converted to level But Quins were back in front five minutes later when winger Charlie Walker darted over from close range following another penalty.
Despite having the majority of possession and territory, Quins had to settle for a 14-14 scoreline at the interval.
Quins have won their last four clashes with Irish and lost just one of their last six visits to Twickenham.
But Quins soon took control as George Lowe put Brown in space and Smith finished off a neat move.
Quins fly-half Chris Malone added two penalties and two conversions, leaving Worcester heading into a six-week Premiership break just four points above bottom club Bristol.
A midfield change of direction by Beim caught Quins out of position for Chris Catling to claim Gloucester's second try.
Quins rugby director John Gallagher said: "What impressed us about David was his one appearance for us last season, against Leicester.
The Quins looked to have won the game going into the final minute after a smart try from scrum half Ifan Beynon-Thomas but a kick and chase try from full back Ed Howley kept Neath's 100% record intact.
one east central 2 September 2017: Llanharan v Rumney, St Josephs v Heol y Cyw, Rhiwbina v Dinas Powys, Treorchy v Glam Wdrs, Llantrisant v Porth Quins, Ystrad Rhondda v Mt Ash.
CARMARTHEN QUINS made it two wins from two after cruising to victory over Llanelli at Carmarthen Park.