References in periodicals archive ?
According to the company, Prolia is the first approved therapy that specifically targets RANK Ligand,an essential regulator of bone-removing cells (osteoclasts).
In recent years, the role of receptor activator of nuclear factor kappa B (RANK), RANK ligand (RANK-L), and the osteoprotegerin (OPG) system has been receiving more research attention in terms of the pathogenesis of CVD.
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis.
XGEVA is a fully human monoclonal antibody that binds to and neutralizes RANK ligand (RANKL)--a protein essential for the formation, function and survival of osteoclasts, which break down bone--thereby inhibiting osteoclast-mediated bone destruction.
Effects of CUR on the Expression Levels of Osteoclast-Specific Gene Markers and RANK Ligand. RT-PCR was used to assess the mRNA expression levels of TRAP, CR, CK, NFATc1, OPG, and RANKL in the calvaria tissue.
Key Words: Bone metastases, cancer-induced bone disease, cancer therapy induced bone loss, skeletal-related event (SRE), bisphosphonates, RANK ligand inhibitors, zoledronic acid, denosumab, hypocalcemia, osteonecrosis of the jaw, skeletal health.
Role of RANK ligand and denosumab, a targeted RANK ligand inhibitor, in bone health and osteoporosis: a review of preclinical and clinical data.
Osteoprotegerin (OPG), the receptor activator of nuclear factor-[kappa]B (RANK), and RANK ligand (RANKL) comprise a system of proteins that play a key role in regulating bone remodeling and are well known as targets for developing therapeutics to treat osteoporosis.
XGEVA binds to RANK Ligand (RANKL), a protein essential for the formation, function and survival of osteoclasts - the cells responsible for bone resorption.
Hata, "Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution," The Journal of Biological Chemistry, vol.