RANK ligand


Also found in: Medical.

RANK ligand

[¦raŋk ′līg·ənd]
(biochemistry)
A local paracrine factor that originates from osteoblasts and mediates the effects of most, if not all, agents that are known to impact osteoclast development in bone. Also known as osteoprotegerin ligand.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
According to the company, Prolia is the first approved therapy that specifically targets RANK Ligand,an essential regulator of bone-removing cells (osteoclasts).
In recent years, the role of receptor activator of nuclear factor kappa B (RANK), RANK ligand (RANK-L), and the osteoprotegerin (OPG) system has been receiving more research attention in terms of the pathogenesis of CVD.
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis.
XGEVA is a fully human monoclonal antibody that binds to and neutralizes RANK ligand (RANKL)--a protein essential for the formation, function and survival of osteoclasts, which break down bone--thereby inhibiting osteoclast-mediated bone destruction.
Effects of CUR on the Expression Levels of Osteoclast-Specific Gene Markers and RANK Ligand. RT-PCR was used to assess the mRNA expression levels of TRAP, CR, CK, NFATc1, OPG, and RANKL in the calvaria tissue.
Key Words: Bone metastases, cancer-induced bone disease, cancer therapy induced bone loss, skeletal-related event (SRE), bisphosphonates, RANK ligand inhibitors, zoledronic acid, denosumab, hypocalcemia, osteonecrosis of the jaw, skeletal health.
Role of RANK ligand and denosumab, a targeted RANK ligand inhibitor, in bone health and osteoporosis: a review of preclinical and clinical data.
Osteoprotegerin (OPG), the receptor activator of nuclear factor-[kappa]B (RANK), and RANK ligand (RANKL) comprise a system of proteins that play a key role in regulating bone remodeling and are well known as targets for developing therapeutics to treat osteoporosis.
XGEVA binds to RANK Ligand (RANKL), a protein essential for the formation, function and survival of osteoclasts - the cells responsible for bone resorption.
Hata, "Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution," The Journal of Biological Chemistry, vol.