According to the company, Prolia is the first approved therapy that specifically targets RANK Ligand
,an essential regulator of bone-removing cells (osteoclasts).
In recent years, the role of receptor activator of nuclear factor kappa B (RANK), RANK ligand
(RANK-L), and the osteoprotegerin (OPG) system has been receiving more research attention in terms of the pathogenesis of CVD.
mediates progestin-induced mammary epithelial proliferation and carcinogenesis.
XGEVA is a fully human monoclonal antibody that binds to and neutralizes RANK ligand
(RANKL)--a protein essential for the formation, function and survival of osteoclasts, which break down bone--thereby inhibiting osteoclast-mediated bone destruction.
Effects of CUR on the Expression Levels of Osteoclast-Specific Gene Markers and RANK Ligand
. RT-PCR was used to assess the mRNA expression levels of TRAP, CR, CK, NFATc1, OPG, and RANKL in the calvaria tissue.
Novel aspects on RANK ligand
and osteoprotegerin in osteoporosis and vascular disease.
Key Words: Bone metastases, cancer-induced bone disease, cancer therapy induced bone loss, skeletal-related event (SRE), bisphosphonates, RANK ligand
inhibitors, zoledronic acid, denosumab, hypocalcemia, osteonecrosis of the jaw, skeletal health.
Role of RANK ligand
and denosumab, a targeted RANK ligand
inhibitor, in bone health and osteoporosis: a review of preclinical and clinical data.
Osteoprotegerin (OPG), the receptor activator of nuclear factor-[kappa]B (RANK), and RANK ligand
(RANKL) comprise a system of proteins that play a key role in regulating bone remodeling and are well known as targets for developing therapeutics to treat osteoporosis.
XGEVA binds to RANK Ligand
(RANKL), a protein essential for the formation, function and survival of osteoclasts - the cells responsible for bone resorption.
Hata, "Crystal structure of the extracellular domain of mouse RANK ligand
at 2.2-A resolution," The Journal of Biological Chemistry, vol.