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Related to REP1: Repone
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Polymorphisms located in the promoter (REP1), introns (rs2736990, rs894278), and 3' region (rs356219 and rs356165) are suggested to be predictors of earlier PD onset in Australian and Chinese [35], Spanish [54], German [46], and UK [61] samples.
As with other gene therapies, a virus was used to insert the DNA for a healthy copy of the REP1 gene into the cells of the patient's eye.
Statistics rep1 rep2 rep3 rep4 Mean 99750 112500 122500 117500 Standard error 7261,485 7500 7500 6291,529 Standard deviation 14522,97 15000 15000 12583,06 Sample variance 2,11E+08 2,25E+08 2,25E+08 1,58E+08 Coefficient of 14,56% 13,33% 12,24% 10,71% Variation (%) Repeatability (r) 2,09563E + 08 -- -- -- Reproducibility (R) 3,82917E + 07 -- -- -- Overall mean: 11306,25 -- -- -- Total standard 15743 -- -- -- deviation Uncertainty of 11858,61 -- -- -- the mean
This pattern is due to the fact that the CMH gene product (REP1) is localized in rods and RPE cells, but not in cones [24].
We also conjecture that the image of the global agencies became tarnished relative to their Japanese counterparts during the crisis (REP1 and REP2).
The researchers examined two risk variants, the REP1 263bp promoter and rs356165.