Following ligation, NLR proteins oligomerize and interact via their CARD domains with adaptor protein, receptor interacting protein kinase 2 (RIP2 or RIPK2
), which is required for both NF-kB and MAPK pathway activation and inflammatory gene expression [55, 56].
Genome-wide association studies (GWAS) have also identified other genes that are functionally related to immunodeficiency, such as RIPK2
, TNFSF15, IFNGR1/2, TYK2, and CARD9 [83-85].
Meditators also expressed HDAC2 and proinflammatory genes RIPK2
and COX-2 at lower levels, resulting in better cortisol recovery in social stress tests, supporting the therapeutic benefits of meditation in treating social stress disorders .